Evidence map›Paper›PMID 33381483›Full record

ReviewFrontiers in pediatrics2020

Current Insights Into Adrenal Insufficiency in the Newborn and Young Infant.

Federica Buonocore, Sinead M McGlacken-Byrne, Ignacio Del Valle, John C Achermann

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Glucocorticoid trajectories in preterm infants-born too soon, wired differently.The Journal of clinical endocrinology and metabolism · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Impact of corticosteroid exposure on preterm labor in neonates eventually born at term.Journal of perinatology : official journal of the California Perinatal Association · 2024
    Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Pediatric Adrenal Insufficiency: Challenges and Solutions.Therapeutics and clinical risk management · 2022
    Review
  13. Can Digenic, Tri-Allelic Inheritance of Variants inFrontiers in endocrinology · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Adrenal insufficiency.Nature reviews. Disease primers · 2021
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Federica BuonocoreGenetics & Genomic Medicine Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
Sinead M McGlacken-ByrneGenetics & Genomic Medicine Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
Ignacio Del ValleGenetics & Genomic Medicine Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
John C AchermannGenetics & Genomic Medicine Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
Great Ormond Street Hospital · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

Adrenal insufficiency (AI) is a potentially life-threatening condition that can be difficult to diagnose, especially if it is not considered as a potential cause of a child's clinical presentation or unexpected deterioration. Children who present with AI in early life can have signs of glucocorticoid deficiency (hyperpigmentation, hypoglycemia, prolonged jaundice, poor weight gain), mineralocorticoid deficiency (hypotension, salt loss, collapse), adrenal androgen excess (atypical genitalia), or associated features linked to a specific underlying condition. Here, we provide an overview of causes of childhood AI, with a focus on genetic conditions that present in the first few months of life. Reaching a specific diagnosis can have lifelong implications for focusing management in an individual, and for counseling the family about inheritance and the risk of recurrence.

Indexed as

Addison's diseaseadrenal hypoplasiaadrenal insufficiencycongenital adrenal hyperplasiaDAX-1genetic testingglucocorticoidMIRAGE syndrome

Identifiers

PMID33381483
PMCPMC7767829
OpenAlexW3111162039

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.