Evidence map›Paper›PMID 33381460›Full record

ArticleFrontiers in oncology2020

A Novel Four-Gene Signature Associated With Immune Checkpoint for Predicting Prognosis in Lower-Grade Glioma.

Youchao Xiao, Gang Cui, Xingguang Ren, Jiaqi Hao, Yu Zhang, Xin Yang, Zhuangzhuang Wang, Xiaolin Zhu, Huan Wang, Chunyan Hao and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Immunotherapy: The Fourth Domain in Oral Cancer Therapeutics.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024
    Article
  4. Article
  5. [Detection of DNA methylation ofNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. Open life sciences · 2021
    Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Youchao XiaoDepartment of Neurosurgery, First Hospital of Shanxi Medical University, Taiyuan, China.
Gang CuiDepartment of Neurosurgery, The Third Affiliated Hospital of Shandong First Medical University (Affiliated Hospital of Shandong Academy of Medical Sciences), Jinan, China.
Xingguang RenDepartment of Neurosurgery, General Hospital of TISCO, Taiyuan, China.
Jiaqi HaoDepartment of Neurosurgery, First Hospital of Shanxi Medical University, Taiyuan, China.
Yu ZhangDepartment of Neurosurgery, First Hospital of Shanxi Medical University, Taiyuan, China.
Xin YangDepartment of Neurosurgery, First Hospital of Shanxi Medical University, Taiyuan, China.
Zhuangzhuang WangDepartment of Neurosurgery, First Hospital of Shanxi Medical University, Taiyuan, China.
Xiaolin ZhuDepartment of Neurosurgery, First Hospital of Shanxi Medical University, Taiyuan, China.
Huan WangDepartment of Neurosurgery, First Hospital of Shanxi Medical University, Taiyuan, China.
Chunyan HaoDepartment of Geriatrics, First Hospital of Shanxi Medical University, Taiyuan, China.
Hubin DuanDepartment of Neurosurgery, First Hospital of Shanxi Medical University, Taiyuan, China.
Shanxi Medical University · CNFirst Hospital of Shanxi Medical University · CNShandong First Medical University · CNTaiyuan Iron and Steel Group (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The overall survival of patients with lower grade glioma (LGG) varies greatly, but the current histopathological classification has limitations in predicting patients' prognosis. Therefore, this study aims to find potential therapeutic target genes and establish a gene signature for predicting the prognosis of LGG. CD44 is a marker of tumor stem cells and has prognostic value in various tumors, but its role in LGG is unclear. By analyzing three glioma datasets from Gene Expression Omnibus (GEO) database, CD44 was upregulated in LGG. We screened 10 CD44-related genes

Indexed as

biomarkercancer stem cellgene signatureimmune checkpointisocitrate dehydrogenase mutationprognostic value

Identifiers

PMID33381460
PMCPMC7769121
OpenAlexW3097908654

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.