Evidence map›Paper›PMID 33381243›Full record

ArticleDisease markers2020

Identification of miRNAs as the Crosstalk in the Interaction between Neural Stem/Progenitor Cells and Endothelial Cells.

Xin Wang, Simin Li, Yihong Ma, Yuzhen Xu, Anthony Chukwunonso Ogbuehi, Xianda Hu, Aneesha Acharya, Rainer Haak, Dirk Ziebolz, Gerhard Schmalz and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease markers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 4 countries.

Xin WangDepartment of Neurology, First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.ORCID https://orcid.org/0000-0001-6998-7040
Simin LiDepartment of Cariology, Endodontology and Periodontology, University Leipzig, Liebigstr. 12, 04103 Leipzig, Germany.ORCID https://orcid.org/0000-0003-4011-0282
Yihong MaDepartment of Neurology, Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.ORCID https://orcid.org/0000-0001-8710-4707
Yuzhen XuDepartment of Neurology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301 Middle Yanchang Road, Shanghai, China.ORCID https://orcid.org/0000-0002-1289-3438
Anthony Chukwunonso OgbuehiFaculty of Physics, University of Münster, Wilhelm-Klemm-Straße 9, 48149 Münster, Germany.ORCID https://orcid.org/0000-0002-6396-3571
Xianda HuLaboratory of Molecular Cell Biology, Beijing Tibetan Hospital, China Tibetology Research Center, 218 Anwaixiaoguanbeili Street, Chaoyang, Beijing 100029, China.ORCID https://orcid.org/0000-0002-3916-6054
Aneesha AcharyaFaculty of Dentistry, University of Hong Kong, Hong Kong, China.ORCID https://orcid.org/0000-0002-9319-6780
Rainer HaakDepartment of Cariology, Endodontology and Periodontology, University Leipzig, Liebigstr. 12, 04103 Leipzig, Germany.ORCID https://orcid.org/0000-0002-3716-4231
Dirk ZiebolzDepartment of Cariology, Endodontology and Periodontology, University Leipzig, Liebigstr. 12, 04103 Leipzig, Germany.ORCID https://orcid.org/0000-0002-9810-2368
Gerhard SchmalzDepartment of Cariology, Endodontology and Periodontology, University Leipzig, Liebigstr. 12, 04103 Leipzig, Germany.ORCID https://orcid.org/0000-0002-6602-377X
Hanluo LiDepartment of Cranio Maxillofacial Surgery, University Clinic Leipzig, Liebigstr. 12, 04103 Leipzig, Germany.ORCID https://orcid.org/0000-0001-9109-2972
Sebastian GausDepartment of Cranio Maxillofacial Surgery, University Clinic Leipzig, Liebigstr. 12, 04103 Leipzig, Germany.ORCID https://orcid.org/0000-0001-8231-9610
Bernd LethausDepartment of Cranio Maxillofacial Surgery, University Clinic Leipzig, Liebigstr. 12, 04103 Leipzig, Germany.ORCID https://orcid.org/0000-0002-9619-9362
Vuk SavkovicDepartment of Cranio Maxillofacial Surgery, University Clinic Leipzig, Liebigstr. 12, 04103 Leipzig, Germany.ORCID https://orcid.org/0000-0003-3832-4281
Zhiqiang SuDepartment of Neurology, First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.ORCID https://orcid.org/0000-0002-5765-9979
Leipzig University · DEUniversity Hospital Leipzig · DEHarbin Medical University · CNChina Tibetology Research Center · CNKumamoto University · JPTongji University · CNUniversity of Hong Kong · HKUniversity of Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThis study is aimed at identifying genetic and epigenetic crosstalk molecules and their target drugs involved in the interaction between neural stem/progenitor cells (NSPCs) and endothelial cells (ECs). MATERIALS AND

methodsDatasets pertaining to reciprocal mRNA and noncoding RNA changes induced by the interaction between NSPCs and ECs were obtained from the GEO database. Differential expression analysis (DEA) was applied to identify NSPC-induced EC alterations by comparing the expression profiles between monoculture of ECs and ECs grown in EC/NSPC cocultures. DEA was also utilized to identify EC-induced NSPC alterations by comparing the expression profiles between monoculture of NSPCs and NSPCs grown in EC/NSPC cocultures. The DEGs and DEmiRNAs shared by NSPC-induced EC alterations and EC-induced NSPC alterations were then identified. Furthermore, miRNA crosstalk analysis and functional enrichment analysis were performed, and the relationship between DEmiRNAs and small molecular drug targets/environment chemical compounds was investigated.

resultsOne dataset (GSE29759) was included and analyzed in this study. Six genes (i.e., MMP14, TIMP3, LOXL1, CCK, SMAD6, and HSPA2), three miRNAs (i.e., miR-210, miR-230a, and miR-23b), and three pathways (i.e., Akt, ERK1/2, and BMPs) were identified as crosstalk molecules. Six small molecular drugs (i.e., deptropine, fluphenazine, lycorine, quinostatin, resveratrol, and thiamazole) and seven environmental chemical compounds (i.e., folic acid, dexamethasone, choline, doxorubicin, thalidomide, bisphenol A, and titanium dioxide) were identified to be potential target drugs of the identified DEmiRNAs.

conclusionTo conclude, three miRNAs (i.e., miR-210, miR-230a, and miR-23b) were identified to be crosstalks linking the interaction between ECs and NSPCs by implicating in both angiogenesis and neurogenesis. These crosstalk molecules might provide a basis for devising novel strategies for fabricating neurovascular models in stem cell tissue engineering.

Indexed as

Neovascularization, PhysiologicNeurogenesisAlgorithmsAnimalsCell CommunicationCoculture TechniquesDatasets as TopicEndothelial CellsGene Expression ProfilingHumansMiceMicroRNAsNeural Stem CellsTranscription FactorsMicroRNAsTranscription Factors

Identifiers

PMID33381243
PMCPMC7758130
OpenAlexW3112175080

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.