Evidence map›Paper›PMID 33381228›Full record

ArticleCardiovascular therapeutics2020

Bazedoxifene Plays a Protective Role against Inflammatory Injury of Endothelial Cells by Targeting CD40.

Wenmin Song, Yu Lv, Zizhao Tang, Fangqin Nie, Panhao Huang, Qi Pei, Ren Guo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular therapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Estrogen Receptor Functions and Pathways at the Vascular Immune Interface.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Wenmin SongDepartment of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, 410013 Hunan, China.
Yu LvDepartment of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, 410013 Hunan, China.
Zizhao TangDepartment of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, 410013 Hunan, China.
Fangqin NieDepartment of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, 410013 Hunan, China.
Panhao HuangDepartment of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, 410013 Hunan, China.
Qi PeiDepartment of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, 410013 Hunan, China.ORCID https://orcid.org/0000-0002-6711-4251
Ren GuoDepartment of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, 410013 Hunan, China.ORCID https://orcid.org/0000-0002-3930-6846
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The inflammatory response and oxidative stress play key roles in the formation and development of atherosclerosis. Bazedoxifene is a new IL6/GP130 inhibitor recommended by the FDA for clinical use as a selective estrogen receptor modulator. However, its role in cardiovascular diseases has been poorly studied. In our study, we explored the mechanism of bazedoxifene's protective effect against inflammatory injury of vascular endothelial cells (VECs) stimulated by TNF-

Indexed as

Anti-Inflammatory AgentsAntioxidantsCD40 AntigensCell AdhesionCell MovementCoculture TechniquesHumansHuman Umbilical Vein Endothelial CellsIndolesInflammationOxidative StressReactive Oxygen SpeciesSignal TransductionTHP-1 CellsTumor Necrosis Factor-alphaAnti-Inflammatory AgentsAntioxidantsbazedoxifeneCD40 AntigensIndolesReactive Oxygen SpeciesTumor Necrosis Factor-alpha

Identifiers

PMID33381228
PMCPMC7755478
OpenAlexW3111719867

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.