ReviewInternational journal of endocrinology2020
The Association of Obesity with Autoimmune Thyroiditis and Thyroid Function-Possible Mechanisms of Bilateral Interaction.
Review in International journal of endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Mediterranean diet, selenium and Graves' ophthalmopathy: a prospective, randomized, single-center study.Endocrine · 2025Trial
- The causal relationship between diabetes mellitus and hashimoto thyroiditis: A two-sample mendelian randomization analysis.Medicine · 2026Article
- Article
- Effects of Sheltering Conditions on Serum Biochemical and Stress Hormone Profiles of Lamb During Cold Exposure.Animals : an open access journal from MDPI · 2026Article
- Differences in Thyroid Autoimmunity and Thyroid Function Tests Between Individuals with and without Obesity: Is There a Correlation with Obesity Degree?Endocrine, metabolic & immune disorders drug targets · 2026Article
- The Influence of Exercise on the Endocrine System: Impacts on Adolescent Growth and Development.Advances in experimental medicine and biology · 2026Review
- Association ofInternational journal of molecular sciences · 2025Article
- A Scoping Review on the Prevalence of Hashimoto's Thyroiditis and the Possible Associated Factors.Medical sciences (Basel, Switzerland) · 2025Article
- Adiposity Is Associated with a Higher Risk of Thyroid Malignancy in Patients with Hashimoto's Thyroiditis.Diagnostics (Basel, Switzerland) · 2025Article
- Endocrine and metabolic comorbidities in juvenile-onset systemic lupus erythematosus.Frontiers in medicine · 2025Article
- Causal association between body mass index and autoimmune thyroiditis: evidence from Mendelian randomization.European journal of medical research · 2023Article
- Transcriptome profiling in rumen, reticulum, omasum, and abomasum tissues during the developmental transition of pre-ruminant to the ruminant in yaks.Frontiers in veterinary science · 2023Article
- Inflammasome activation as a link between obesity and thyroid disorders: Implications for an integrated clinical management.Frontiers in endocrinology · 2022Review
- Gender-Specific Impact of Metabolic Obesity Phenotypes on the Risk of Hashimoto's Thyroiditis: A Retrospective Data Analysis Using a Health Check-Up Database.Journal of inflammation research · 2022Article
- Review
- Diet and Hygiene in Modulating Autoimmunity During the Pandemic Era.Frontiers in immunology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A growing number of patients suffer from autoimmune diseases, including autoimmune thyroid disease. There has simultaneously been a significant increase in the prevalence of obesity worldwide. It is still an open question whether adiposity can directly influence activation of inflammatory processes affecting the thyroid in genetically predisposed individuals. Adipokines, biologically active substances derived from the adipocytes, belong to a heterogenic group of compounds involved in numerous physiological functions, including the maintenance of metabolism, hormonal balance, and immune response. Notably, the presence of obesity worsens the course of selected autoimmune diseases and impairs response to treatment. Moreover, the excess of body fat may result in the progression of autoimmune diseases. Nutritional status, body weight, and energy expenditure may influence thyroid hormone secretion. Interestingly, thyroid hormones might influence the activity of adipose tissue as metabolic alterations related to fat tissue are observed under pathological conditions in which there are deficits or overproduction of thyroid hormones. Functioning TSH receptors are expressed on adipocytes. Thermogenesis may presumably be stimulated by TSH binding to its receptor on brown adipocytes. There could be a bilateral interaction between the thyroid and adipose. Obesity may influence the onset and course of autoimmune disease.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.