Evidence map›Paper›PMID 33381046›Full record

ArticleFrontiers in pharmacology2020

Astragalus Flavone Ameliorates Atherosclerosis and Hepatic Steatosis Via Inhibiting Lipid-Disorder and Inflammation in apoE

Chuanrui Ma, Jing Zhang, Shu Yang, Yunqing Hua, Jing Su, Yuna Shang, Zhongyan Wang, Ke Feng, Jian Zhang, Xiaoxiao Yang and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Study on subtyping and Traditional Chinese Medicine treatment of depression based on machine learning and text mining.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025
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  4. Research Progress on Chemical Components ofMolecules (Basel, Switzerland) · 2025
    Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Cancer management and research · 2024
    Review
  11. Exploratory review on the effect ofFrontiers in pharmacology · 2024
    Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Mechanism ofNutrients · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Chuanrui MaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Jing ZhangFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Shu YangDepartment of Endocrinology, The Second Clinical Medical College, Shenzhen People's Hospital, Jinan University, Shenzhen, China.
Yunqing HuaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Jing SuTianjin State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Yuna ShangCollege of Life Sciences, Nankai University, Tianjin, China.
Zhongyan WangTianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China.
Ke FengCollege of Life Sciences, Nankai University, Tianjin, China.
Jian ZhangDepartment of Pharmacology, College of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
Xiaoxiao YangKey Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, College of Food and Biological Engineering, Hefei University of Technology, Hefei, China.
Hao ZhangFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Jingyuan MaoFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Guanwei FanFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine · CNNankai University · CNTianjin Medical University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNHefei University of Technology · CNJinan University · CNTianjin University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerosis is a major pathogenic driver of cardiovascular diseases. Foam cell formation plays a key role in atherogenesis, which is affected by lipid disorder and inflammation. Therefore, inhibition of foam cell formation is a therapeutic approach for atherosclerosis treatment. Total flavone of

Indexed as

Astragalus flavoneatherosclerosishepatic steatosisinflammationlipid disorder

Identifiers

PMID33381046
PMCPMC7768082
OpenAlexW3112005114

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.