Evidence map›Paper›PMID 33381018›Full record

ArticleFrontiers in computational neuroscience2020

Can Tumor Location on Pre-treatment MRI Predict Likelihood of Pseudo-Progression vs. Tumor Recurrence in Glioblastoma?-A Feasibility Study.

Marwa Ismail, Virginia Hill, Volodymyr Statsevych, Evan Mason, Ramon Correa, Prateek Prasanna, Gagandeep Singh, Kaustav Bera, Rajat Thawani, Manmeet Ahluwalia and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in computational neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Marwa IsmailDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States.
Virginia HillDepartment of Neuroradiology, Imaging Institute, Cleveland Clinic, Cleveland, OH, United States.
Volodymyr StatsevychDepartment of Neuroradiology, Imaging Institute, Cleveland Clinic, Cleveland, OH, United States.
Evan MasonDepartment of Neuroradiology, Imaging Institute, Cleveland Clinic, Cleveland, OH, United States.
Ramon CorreaDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States.
Prateek PrasannaDepartment of Biomedical Informatics, Stony Brook University, Stony Brook, NY, United States.
Gagandeep SinghDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States.
Kaustav BeraDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States.
Rajat ThawaniDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States.
Manmeet AhluwaliaBrain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, OH, United States.
Anant MadabhushiDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States.
Pallavi TiwariDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States.
Case Western Reserve University · USCleveland Clinic · USLouis Stokes Cleveland VA Medical Center · USMaimonides Medical Center · USStony Brook University · US

Funding

Computerized histologic image predictor of cancer outcomeR01CA202752 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI FELDMAN, MICHAEL D, GANESAN, SHRIDAR · 2016 to 2020
$3.1M
Quantitative Histomorphometric Risk Classifier (QuHbIC) in HPV + Oropharyngeal CarcinomaR01CA220581 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI KOYFMAN, SHLOMO, LEWIS, JAMES · 2018 to 2023
$3.1M
Computerized Histologic Risk Predictor (CHiRP) for Early Stage Lung CancersR01CA216579 · NCI · EMORY UNIVERSITY · PI FU, PINGFU, LLOYD, MARK · 2018 to 2023
$3.1M
MR Fingerprinting and Computerized Decision Support for Prostate CancerR01CA208236 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GULANI, VIKAS, PONSKY, LEE EVAN · 2017 to 2022
$3.0M
Pathology Image Informatics Platform for visualization, analysis and managementU24CA199374 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI GURCAN, METIN NAFI, MADABHUSHI, ANANT · 2015 to 2019
$2.9M
RadxTools for assessing tumor treatment response on imagingU01CA248226 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI TIWARI, PALLAVI, VISWANATH, SATISH EASWAR · 2020 to 2022
$1.4M
BIOMEDICAL ENGINEERING RESEARCH FACILITIESC06RR012463 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI KUTINA, KENNETH L · 1997 to 1997
–
NCI NIH HHS R01 CA202752NCI NIH HHS R01 CA208236NCI NIH HHS R01 CA216579NCI NIH HHS R01 CA220581NCI NIH HHS U24 CA199374NCRR NIH HHS C06 RR012463
6 · The paper itself

Abstract

A significant challenge in Glioblastoma (GBM) management is identifying pseudo-progression (PsP), a benign radiation-induced effect, from tumor recurrence, on routine imaging following conventional treatment. Previous studies have linked tumor lobar presence and laterality to GBM outcomes, suggesting that disease etiology and progression in GBM may be impacted by tumor location. Hence, in this feasibility study, we seek to investigate the following question: Can tumor location on treatment-naïve MRI provide early cues regarding likelihood of a patient developing pseudo-progression vs. tumor recurrence? In this study, 74 pre-treatment Glioblastoma MRI scans with PsP (33) and tumor recurrence (41) were analyzed. First, enhancing lesion on Gd-T

Indexed as

ADIFFIatlasglioblastomapseudo-progressiontumor recurrence

Identifiers

PMID33381018
PMCPMC7767991
OpenAlexW3112084279

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.