Evidence map›Paper›PMID 33380935›Full record

ReviewThe Yale journal of biology and medicine2020

Food Allergy: Searching for the Modern Environmental Culprit.

Anna S Eisenstein, Brandon Hilliard, Sophia Silwal, Andrew Wang

Open access · greenAbstract readReview
In one paragraph

Review in The Yale journal of biology and medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Anna S EisensteinDepartment of Dermatology, Yale University School of Medicine, New Haven, CT.
Brandon HilliardDepartment of Dermatology, Yale University School of Medicine, New Haven, CT.
Sophia SilwalYale University, New Haven, CT.
Andrew WangDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT.
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Training in Investigative DermatologyT32AR007016 · NIAMS · YALE UNIVERSITY · PI KEITH A CHOATE, MICHAEL GIRARDI · 1986 to 2026
$7.8M
Regulation of Metabolic Programs for Host Tolerance to InflammationK08AI128745 · NIAID · YALE UNIVERSITY · PI WANG, ANDREW · 2017 to 2021
$784k
NCATS NIH HHS UL1 TR001863NIAID NIH HHS K08 AI128745NIAMS NIH HHS T32 AR007016
6 · The paper itself

Abstract

Food allergy is a modern disease. Its exponential increase in prevalence in the last 70 years cannot be explained by genetic factors alone. In this review we discuss the hypotheses that have been suggested previously, and the evidence that supports them, to explain this rise in prevalence as well as the medical treatments that have developed as a result of basic exploration within these paradigms. We argue that one major area of fruitful exploration that would help generate new ideas may be systematic analyses of the unknown factors of the modern environment that may contribute to the formation of food allergy. Through this lens, we review the current understanding of food allergy pathogenesis and propose novel research directions, with implications for the current strategies for managing food allergy.

Indexed as

Food HypersensitivityHumansPrevalenceevolutionary mismatchfood allergytype II immunity

Identifiers

PMID33380935
PMCPMC7757057
OpenAlexW3113681840

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.