ArticleNeurology2021
Hypertensive Disorders of Pregnancy and Cognitive Impairment: A Prospective Cohort Study.
Article in Neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 4 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Associations between adverse pregnancy outcomes and cognitive impairment and dementia: a systematic review and meta-analysis.The lancet. Healthy longevity · 2024Pooled it
- Temporal patterns of pre- and post-natal target organ damage associated with hypertensive pregnancy: a systematic review.European journal of preventive cardiology · 2024Pooled it
- Association Between Hypertensive Disorders of Pregnancy and Dementia: a Systematic Review and Meta-Analysis.Hypertension (Dallas, Tex. : 1979) · 2023Pooled it
- Preeclampsia and its relationship to pathological brain aging.Frontiers in physiology · 2022Pooled it
- Impaired Hearing and Systolic Blood Pressure as Potential Markers of Cerebral Infarction After Eclampsia: A Cross-Sectional Study.BJOG : an international journal of obstetrics and gynaecology · 2026Observational
- Association of borderline hypertension defined by ACC-AHA diagnostic criteria during pregnancy with neurodevelopment in infants.BMC medicine · 2026Article
- Preeclampsia as a reversible risk factor for Alzheimer's disease: A prospective MRI study on morphological changes of the cerebral cortex and impairment of cognitive functions.The journal of prevention of Alzheimer's disease · 2026Article
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- Adverse Pregnancy Outcomes and Cognitive Change in Older Women.Journal of women's health (2002) · 2026Article
- The association between mean arterial pressure and memory decline in preeclampsia patients: a mediation analysis of serum amyloid-β 1-42 and phosphorylated tau 181.BMC pregnancy and childbirth · 2025Article
- Hypertension in Pregnancy Linked to Cerebral Small Vessel Disease 15 Years Later.Hypertension (Dallas, Tex. : 1979) · 2025Article
- History of hypertensive disorders of pregnancy and risk of Alzheimer's disease and vascular dementia.Frontiers in neuroendocrinology · 2025Review
- Hypertensive Disorders of Pregnancy and Brain Health in Midlife: The CARDIA Study.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Gestational Hypertension, Preeclampsia, and Eclampsia and Future Neurological Disorders.JAMA neurology · 2025Article
- Effect of aerobic exercise combined with systematic nursing on psychological status and pregnancy outcomes in patients with gestational hypertension.American journal of translational research · 2025Article
- Maternal and fetal neurocognitive outcomes in preeclampsia and eclampsia; a narrative review of current evidence.European journal of medical research · 2024Review
- Postpartum and interpregnancy care of women with a history of hypertensive disorders of pregnancy.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Review
- Hypertensive disorders of pregnancy and midlife maternal cognition in a prospective cohort study.Journal of clinical hypertension (Greenwich, Conn.) · 2024Article
- Impact of adverse pregnancy outcomes on brain vascular health and cognition.Research and practice in thrombosis and haemostasis · 2024Article
- Article
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7 authors at 1 institution in 2 countries.
Funding
Abstract
objectiveTo determine the association between hypertensive disorders of pregnancy (HDP) and cognitive impairment 15 years after pregnancy, we measured cognitive performance in 115 women with a history of HDP and in 481 women with a previous normotensive pregnancy.
methodsThis was a nested cohort study embedded in a population-based prospective cohort from early pregnancy onwards. Cognitive function was assessed with cognitive tests 15 years after the index pregnancy (median 14.7 years, 90% range [13.9-16.1]). Cognitive performance was measured in different cognitive domains: executive function, processing speed, verbal memory, motor function, and visuospatial ability. A global cognition factor (g-factor) was derived from principal component analysis.
resultsOf the women with HDP, 80 (69.6%) had gestational hypertension (GH) and 35 (30.4%) had preeclampsia. Women with HDP had a lower g-factor than women with a previous normotensive pregnancy (mean -0.22, 90% range [-2.06-1.29]). HDP was negatively associated with the 15-word learning test: immediate recall (-0.25, 95% CI [-0.44 to -0.06]) and delayed recall (-0.30, 95% CI [-0.50 to -0.10]). Women with GH perform significantly worse on their 15-word learning test than women with a previous normotensive pregnancy.
conclusionA history of HDP is independently associated with poorer working memory and verbal learning 15 years after pregnancy. This association is mainly driven by women with GH. Clinicians and women who experienced HDP should be aware of this risk.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.