Evidence map›Paper›PMID 33380493›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2021

Anna M Gram, John A Wright, Robert J Pickering, Nathaniel L Lam, Lee M Booty, Steve J Webster, Clare E Bryant

Open access · hybridAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 98 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
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  6. Article
  7. An overview of human inflammasomes: Activation and regulation.Journal of immunology (Baltimore, Md. : 1950) · 2026
    Review
  8. Article
  9. Article
  10. Review
  11. Molecular strategies ofFrontiers in cellular and infection microbiology · 2026
    Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Deficiency in theMicroorganisms · 2025
    Article
  18. Review
  19. Article
  20. Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 5 countries.

Anna M GramImmunology Catalyst Programme, GlaxoSmithKline, Stevenage SG1 2NY, United Kingdom.
John A WrightImmunology Catalyst Programme, GlaxoSmithKline, Stevenage SG1 2NY, United Kingdom.ORCID 0000-0002-9758-9944
Robert J PickeringImmunology Catalyst Programme, GlaxoSmithKline, Stevenage SG1 2NY, United Kingdom.ORCID 0000-0003-3332-9868
Nathaniel L LamImmunology Catalyst Programme, GlaxoSmithKline, Stevenage SG1 2NY, United Kingdom.ORCID 0000-0003-3255-8642
Lee M BootyImmunology Catalyst Programme, GlaxoSmithKline, Stevenage SG1 2NY, United Kingdom.ORCID 0000-0003-3003-5872
Steve J WebsterDepartment of Veterinary Medicine, The University of Cambridge, Cambridge CB3 OES, United Kingdom.ORCID 0000-0002-0864-1182
Clare E BryantImmunology Catalyst Programme, GlaxoSmithKline, Stevenage SG1 2NY, United Kingdom; ceb27@cam.ac.uk.
GlaxoSmithKline (United Kingdom) · GBUniversity of Cambridge · GB

Funding

Wellcome Trust 108045
6 · The paper itself

Abstract

Infection of human macrophages with

Indexed as

ApoptosisCalcium-Binding ProteinsCARD Signaling Adaptor ProteinsCaspases, InitiatorFlagellinHumansInflammasomesMacrophagesNeuronal Apoptosis-Inhibitory ProteinNLR Family, Pyrin Domain-Containing 3 ProteinReactive Oxygen SpeciesSalmonella typhiSignal TransductionTHP-1 CellsType III Secretion SystemsTyphoid FeverCalcium-Binding ProteinsCARD Signaling Adaptor ProteinsCASP4 protein, humanCaspases, InitiatorFlagellinInflammasomesNeuronal Apoptosis-Inhibitory ProteinNLRC4 protein, humanNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanReactive Oxygen SpeciesType III Secretion Systems

Identifiers

PMID33380493
PMCPMC7812056
OpenAlexW3112472197

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.