Evidence map›Paper›PMID 33380469›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

α3* Nicotinic Acetylcholine Receptors in the Habenula-Interpeduncular Nucleus Circuit Regulate Nicotine Intake.

Karim S Elayouby, Masago Ishikawa, Angeline J Dukes, Alexander C W Smith, Qun Lu, Christie D Fowler, Paul J Kenny

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Ibogaine for Substance Use Disorders.Advances in therapy · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Targeting GPR3 as a novel approach for nicotine cessation therapeutic development.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  9. Review
  10. The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Neurobiology of Stress-Induced Nicotine Relapse.International journal of molecular sciences · 2024
    Review
  18. Article
  19. Article
  20. Nicotine addiction: More than just dopamine.Current opinion in neurobiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Karim S ElayoubyNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
Masago IshikawaNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York 10029.
Angeline J DukesDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, California 92697.
Alexander C W SmithNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York 10029.ORCID 0000-0001-7724-6234
Qun LuDepartment of Molecular Medicine, Scripps Research, Jupiter, Florida 33458.
Christie D FowlerDepartment of Neurobiology and Behavior, University of California Irvine, Irvine, California 92697 cdfowler@uci.edu paul.kenny@mssm.edu.ORCID 0000-0003-2864-2163
Paul J KennyNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York 10029 cdfowler@uci.edu paul.kenny@mssm.edu.

Funding

Role for Tas2Rs in opioid addictionR37DA020686 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Paul J. Kenny · 2018 to 2026
$3.7M
Mechanisms of nicotine reinforcement in miceR01DA020686 · NIDA · SCRIPPS RESEARCH INSTITUTE, THE · PI KENNY, PAUL J. · 2007 to 2016
$3.6M
The Habenulo-Interpeduncular Pathway and NicotineR00DA032543 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI FOWLER, CHRISTIE D · 2014 to 2016
$741k
The Habenulo-Interpeduncular Pathway and NicotineK99DA032543 · NIDA · SCRIPPS FLORIDA · PI FOWLER, CHRISTIE D · 2012 to 2013
$297k
NIDA NIH HHS K99 DA032543NIDA NIH HHS R00 DA032543NIDA NIH HHS R01 DA020686NIDA NIH HHS R37 DA020686
6 · The paper itself

Abstract

Allelic variation in

Indexed as

AnimalsFemaleGenetic Predisposition to DiseaseGenetic VariationHabenulaInterpeduncular NucleusMaleMiceMice, Inbred BALB CRatsRats, WistarReceptors, NicotinicTobacco Use Disordernicotinic receptor alpha3beta4Receptors, NicotinicaddictionCHRNA3habenulainterpeduncular nucleusnicotineself-administration

Identifiers

PMID33380469
PMCPMC8115890

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.