Evidence map›Paper›PMID 33380422›Full record

ArticleThe Journal of biological chemistry

Cell autonomous angiotensin II signaling controls the pleiotropic functions of oncogenic K-Ras.

Daniela Volonte, Morgan Sedorovitz, Victoria E Cespedes, Maria L Beecher, Ferruccio Galbiati

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Daniela VolonteDepartment of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Morgan SedorovitzDepartment of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Victoria E CespedesDepartment of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Maria L BeecherDepartment of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Ferruccio GalbiatiDepartment of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Electronic address: feg5@pitt.edu.
University of Pittsburgh · US

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHN C. BYRD · 1988 to 2026
$158.0M
Mechanisms that control the progression from premalignant lesions to adenocarcinomas in the lungR01CA205165 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GALBIATI, FERRUCCIO · 2017 to 2021
$1.6M
PTRF, a novel regulator of oncogene-induced senescenceR21AG061614 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VOLONTE, DANIELA · 2019 to 2020
$430k
NCI NIH HHS P30 CA047904NCI NIH HHS R01 CA205165NIA NIH HHS R21 AG061614
6 · The paper itself

Abstract

Oncogenic K-Ras (K-Ras

Indexed as

Angiotensin IIAngiotensinogenAnimalsGene Expression Regulation, NeoplasticHumansHypertensionKidney Tubules, ProximalKruppel-Like Factor 6LosartanLung NeoplasmsMiceOxidative StressProto-Oncogene Proteins p21(ras)Receptor, Angiotensin, Type 1Renin-Angiotensin SystemSTAT3 Transcription FactorAGT protein, humanAGTR1 protein, humanAngiotensin IIAngiotensinogenHras protein, mouseKruppel-Like Factor 6LosartanProto-Oncogene Proteins p21(ras)Receptor, Angiotensin, Type 1Stat3 protein, mouseSTAT3 Transcription FactorangiotensincaveolinoncogeneRassenescence

Identifiers

PMID33380422
PMCPMC7948762
OpenAlexW3116780487

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.