Evidence map›Paper›PMID 33380406›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2020

[SBi4211 alleviates gp120-induced central nervous system injury

Shaojie Yang, Xiaoyan Deng, Tiesong Zhang, Yi Xiao, Liang Peng, Li Li, Xiaolong He, Yi Wei, Liqun Liu, Hong Cao and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Shaojie YangDepartment of Microbiology, Guangdong Provincial Key Laboratory of Tropical Diseases Research, School of Public Health, Southern Medical University, Guangzhou 510515, China.
Xiaoyan DengKingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou 511436, China.
Tiesong ZhangKunming Key Laboratory of Children Infection and Immunity, Yunnan Institute of Pediatrics, Kunming Children's Hospital, Kunming 650228, China.
Yi XiaoDepartment of Clinical Laboratory, Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou 510700, China.
Liang PengDepartment of Clinical Laboratory, Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou 510700, China.
Li LiKunming Key Laboratory of Children Infection and Immunity, Yunnan Institute of Pediatrics, Kunming Children's Hospital, Kunming 650228, China.
Xiaolong HeDepartment of Microbiology, Guangdong Provincial Key Laboratory of Tropical Diseases Research, School of Public Health, Southern Medical University, Guangzhou 510515, China.
Yi WeiDepartment of Microbiology, Guangdong Provincial Key Laboratory of Tropical Diseases Research, School of Public Health, Southern Medical University, Guangzhou 510515, China.
Liqun LiuDepartment of Pediatrics, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Hong CaoDepartment of Microbiology, Guangdong Provincial Key Laboratory of Tropical Diseases Research, School of Public Health, Southern Medical University, Guangzhou 510515, China.
Beiguo LongDepartment of Microbiology, Guangdong Provincial Key Laboratory of Tropical Diseases Research, School of Public Health, Southern Medical University, Guangzhou 510515, China.
Shenghe HuangDepartment of Microbiology, Guangdong Provincial Key Laboratory of Tropical Diseases Research, School of Public Health, Southern Medical University, Guangzhou 510515, China.
Central South University · CNGuangzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the protective effect of SBi4211 (heptamidine), an inhibitor of S100B, against central nervous system injury induced by HIV-1 envelope protein gp120.

methodsIn an

resultsIn the cell co-culture system, SBi4211 treatment significantly inhibited gp120-induced expression of S100B, RAGE and GFAP in U251 cells (

conclusionsSBi4211 can protect neurons from gp120-induced neurotoxicity possibly by inhibiting the S100B/ RAGE-mediated signaling pathway.

Indexed as

AstrocytesNeuronsAnimalsBlotting, WesternCentral Nervous SystemHIV Envelope Protein gp120MiceS100 Calcium Binding Protein beta SubunitSignal TransductionHIV Envelope Protein gp120S100b protein, mouseS100 Calcium Binding Protein beta Subunitgp120HIV-associated neurocognitive disorderS100B/RAGESBi4211

Identifiers

PMID33380406
PMCPMC7835702
OpenAlexW3115412312

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.