Evidence map›Paper›PMID 33380173›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2021

Helix-Loop-Helix Factor Id3 (Inhibitor of Differentiation 3): A Novel Regulator of Hyaluronan-Mediated Adipose Tissue Inflammation.

Angelina Misiou, James C Garmey, Jack M Hensien, Daniel B Harmon, Victoria Osinski, Chantel McSkimming, Melissa A Marshall, Jens W Fischer, Maria Grandoch, Coleen A McNamara

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. The thrombin receptor PAR4 supports visceral adipose tissue inflammation.Naunyn-Schmiedeberg's archives of pharmacology · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

Angelina MisiouInstitute of Pharmacology and Clinical Pharmacology, Medical Faculty, Heinrich-Heine-Universität Düsseldorf, Germany (A.M., J.W.F., M.G.).
James C GarmeyRobert M. Berne Cardiovascular Research Center (J.C.G., J.M.H., D.B.H., V.O., C.M., M.A.M., C.A.M.), University of Virginia, Charlottesville.
Jack M HensienRobert M. Berne Cardiovascular Research Center (J.C.G., J.M.H., D.B.H., V.O., C.M., M.A.M., C.A.M.), University of Virginia, Charlottesville.
Daniel B HarmonRobert M. Berne Cardiovascular Research Center (J.C.G., J.M.H., D.B.H., V.O., C.M., M.A.M., C.A.M.), University of Virginia, Charlottesville.
Victoria OsinskiRobert M. Berne Cardiovascular Research Center (J.C.G., J.M.H., D.B.H., V.O., C.M., M.A.M., C.A.M.), University of Virginia, Charlottesville.
Chantel McSkimmingRobert M. Berne Cardiovascular Research Center (J.C.G., J.M.H., D.B.H., V.O., C.M., M.A.M., C.A.M.), University of Virginia, Charlottesville.
Melissa A MarshallRobert M. Berne Cardiovascular Research Center (J.C.G., J.M.H., D.B.H., V.O., C.M., M.A.M., C.A.M.), University of Virginia, Charlottesville.
Jens W FischerInstitute of Pharmacology and Clinical Pharmacology, Medical Faculty, Heinrich-Heine-Universität Düsseldorf, Germany (A.M., J.W.F., M.G.).
Maria GrandochInstitute of Pharmacology and Clinical Pharmacology, Medical Faculty, Heinrich-Heine-Universität Düsseldorf, Germany (A.M., J.W.F., M.G.).
Coleen A McNamaraRobert M. Berne Cardiovascular Research Center (J.C.G., J.M.H., D.B.H., V.O., C.M., M.A.M., C.A.M.), University of Virginia, Charlottesville.
Mahindra and Mahindra Limited (India) · INHeinrich Heine University Düsseldorf · DE

Funding

Local B-1 Regulation of AtherosclerosisR01HL136098 · NHLBI · UNIVERSITY OF VIRGINIA · PI MCNAMARA, COLEEN A · 2017 to 2020
$3.1M
Training Program in Cardiac InnovationT32HL144472 · NHLBI · UNIVERSITY OF MINNESOTA · PI Peter A Crawford, SAMUEL C DUDLEY · 2019 to 2026
$2.6M
NHLBI NIH HHS R01 HL136098NHLBI NIH HHS T32 HL144472
6 · The paper itself

Abstract

objectiveThe aim of this study was to unravel mechanisms whereby deficiency of the transcription factor Id3 (inhibitor of differentiation 3) leads to metabolic dysfunction in visceral obesity. We investigated the impact of loss of Id3 on hyaluronic acid (HA) production by the 3 HAS isoenzymes (HA synthases; -1, -2, and -3) and on obesity-induced adipose tissue (AT) accumulation of proinflammatory B cells. Approach and Results: Male

conclusionsOur data demonstrate that loss of

Indexed as

Adipose TissueAnimalsB-LymphocytesCell AdhesionCells, CulturedCoculture TechniquesDiet, High-FatDisease Models, AnimalHyaluronan SynthasesHyaluronic AcidInhibitor of Differentiation ProteinsMacrophagesMaleMiceMice, Inbred C57BLMice, KnockoutHas2 protein, mouseHyaluronan SynthasesHyaluronic AcidIdb3 protein, mouseInhibitor of Differentiation Proteinsadipose tissuehyaluronic acidinflammationobesity

Identifiers

PMID33380173
PMCPMC8105274
OpenAlexW3114501838

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.