Evidence map›Paper›PMID 33379925›Full record

ArticleThe Journal of the Acoustical Society of America2020

Bilayer aberration-inducing gel phantom for high intensity focused ultrasound applications.

Alex T Peek, Christopher Hunter, Wayne Kreider, Tatiana D Khokhlova, Pavel B Rosnitskiy, Petr V Yuldashev, Oleg A Sapozhnikov, Vera A Khokhlova

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of the Acoustical Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Overview of Therapeutic Ultrasound Applications and Safety Considerations: 2024 Update.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025
    Review
  4. Article
  5. Aberration correction in abdominal histotripsy.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2023
    Review
  6. Article
  7. Phase-Aberration Correction for HIFU Therapy Using a Multielement Array and Backscattering of Nonlinear Pulses.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alex T PeekCenter for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, 1013 NE 40th Street, Seattle, Washington 98105, USA.
Christopher HunterCenter for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, 1013 NE 40th Street, Seattle, Washington 98105, USA.
Wayne KreiderCenter for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, 1013 NE 40th Street, Seattle, Washington 98105, USA.
Tatiana D KhokhlovaDivision of Gastroenterology, Department of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98195, USA.
Pavel B RosnitskiyDepartment of Acoustics, Physics Faculty, Moscow State University, Leninskie Gory, Moscow 119991, Russia.
Petr V YuldashevDepartment of Acoustics, Physics Faculty, Moscow State University, Leninskie Gory, Moscow 119991, Russia.
Oleg A SapozhnikovDepartment of Acoustics, Physics Faculty, Moscow State University, Leninskie Gory, Moscow 119991, Russia.
Vera A KhokhlovaDepartment of Acoustics, Physics Faculty, Moscow State University, Leninskie Gory, Moscow 119991, Russia.ORCID s0000000225858228

Funding

Nonlinear Acoustics in Calibration/Metrology of High Intensity Focused UltrasoundR01EB007643 · NIBIB · UNIVERSITY OF WASHINGTON · PI KHOKHLOVA, VERA · 2008 to 2020
$6.9M
Strategies in therapeutic ultrasound for predicting in situ fields and quantifying the impact of tissue inhomogeneitiesR01EB025187 · NIBIB · UNIVERSITY OF WASHINGTON · PI SAPOZHNIKOV, OLEG · 2018 to 2021
$2.1M
Histotripsy liquefaction of clinically significant hematomasR01GM122859 · NIGMS · UNIVERSITY OF WASHINGTON · PI KHOKHLOVA, TATIANA · 2017 to 2020
$1.2M
NIBIB NIH HHS R01 EB007643NIBIB NIH HHS R01 EB025187NIGMS NIH HHS R01 GM122859
6 · The paper itself

Abstract

Aberrations induced by soft tissue inhomogeneities often complicate high-intensity focused ultrasound (HIFU) therapies. In this work, a bilayer phantom made from polyvinyl alcohol hydrogel and ballistic gel was built to mimic alternating layers of water-based and lipid tissues characteristic of an abdominal body wall and to reproducibly distort HIFU fields. The density, sound speed, and attenuation coefficient of each material were measured using a homogeneous gel layer. A surface with random topographical features was designed as an interface between gel layers using a 2D Fourier spectrum approach and replicating different spatial scales of tissue inhomogeneities. Distortion of the field of a 256-element 1.5 MHz HIFU array by the phantom was characterized through hydrophone measurements for linear and nonlinear beam focusing and compared to the corresponding distortion induced by an ex vivo porcine body wall of the same thickness. Both spatial shift and widening of the focal lobe were observed, as well as dramatic reduction in focal pressures caused by aberrations. The results suggest that the phantom produced levels of aberration that are similar to a real body wall and can serve as a research tool for studying HIFU effects as well as for developing algorithms for aberration correction.

Indexed as

High-Intensity Focused Ultrasound AblationAlgorithmsAnimalsPhantoms, ImagingPressureSwineWaterWater

Identifiers

PMID33379925
PMCPMC8097711

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.