ArticleThe Journal of the Acoustical Society of America2020
How electrically evoked compound action potentials in chronically implanted guinea pigs relate to auditory nerve health and electrode impedance.
Article in The Journal of the Acoustical Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Age-dependent Shifts in Spiral Ganglion Neuron Subtypes Are Associated with Interphase Gap-dependent Modulation of Electrically Evoked Compound Action Potentials in Mice.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Establishing reliable neural health measures in adult cochlear implant users.Frontiers in neuroscience · 2026Article
- Contributions of Auditory Nerve Density and Synchrony to Speech Understanding in Older Cochlear Implant Users.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- An Electrically Evoked Compound Action Potential Marker for Local Spiral Ganglion Neuron Degeneration: The Failure Index.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Comparing Patient-Specific Variations in Intra-Cochlear Neural Health Estimated Using Psychophysical Thresholds and Panoramic Electrically Evoked Compound Action Potentials (PECAPs).Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- Contribution of macrophages to neural survival and intracochlear tissue remodeling responses following cochlear implantation.Journal of neuroinflammation · 2023Article
- Reexamining the effects of electrode location on measures of neural health in cochlear implant users.JASA express letters · 2023Article
- Cochlear Health and Cochlear-implant Function.Journal of the Association for Research in Otolaryngology : JARO · 2023Review
- Changes in the Electrically Evoked Compound Action Potential over time After Implantation and Subsequent Deafening in Guinea Pigs.Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- Cochlear implants: Causes, effects and mitigation strategies for the foreign body response and inflammation.Hearing research · 2022Review
- Interpreting the interphase gap effect on the electrically evoked compound action potential.JASA express letters · 2022Article
- Combined brain-derived neurotrophic factor and neurotrophin-3 treatment is preferred over either one separately in the preservation of the auditory nerve in deafened guinea pigs.Frontiers in molecular neuroscience · 2022Article
- Vibration and Trajectory Tracking Control of Engineering Mechanical Arm Based on Neural Network.Computational intelligence and neuroscience · 2022Article
- Using the electrically-evoked compound action potential (ECAP) interphase gap effect to select electrode stimulation sites in cochlear implant users.Hearing research · 2021Article
- Development of a chronically-implanted mouse model for studies of cochlear health and implant function.Hearing research · 2021Article
- Effects of Electrode Location on Estimates of Neural Health in Humans with Cochlear Implants.Journal of the Association for Research in Otolaryngology : JARO · 2020Article
- Article
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
This study examined how multiple measures based on the electrically evoked compound action potential (ECAP) amplitude-growth functions (AGFs) were related to estimates of neural [spiral ganglion neuron (SGN) density and cell size] and electrode impedance measures in 34 specific pathogen free pigmented guinea pigs that were chronically implanted (4.9-15.4 months) with a cochlear implant electrode array. Two interphase gaps (IPGs) were used for the biphasic pulses and the effect of the IPG on each ECAP measure was measured ("IPG effect"). When using a stimulus with a constant IPG, SGN density was related to the across-subject variance in ECAP AGF linear slope, peak amplitude, and N1 latency. The SGN density values also help to explain a significant proportion of variance in the IPG effect for AGF linear slope and peak amplitude measures. Regression modeling revealed that SGN density was the primary dependent variable contributing to across-subject variance for ECAP measures; SGN cell size did not significantly improve the fitting of the model. Results showed that simple impedance measures were weakly related to most ECAP measures but did not typically improve the fit of the regression model.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.