ReviewMolecules (Basel, Switzerland)2020
Difunctionalization of Alkenes and Alkynes via Intermolecular Radical and Nucleophilic Additions.
Review in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 128 citations in OpenAlex.
- Modular Access to α-Tertiary Amines: Electrochemical Tandem Di-Functionalization of Olefins With Ammonia Surrogates and Amino Acids.Angewandte Chemie (International ed. in English) · 2026Article
- Direct halo-/seleno-sulfonylation and diselenylation of ynamides mediated by visible light.RSC advances · 2026Article
- Remote 1,5-Difunctionalization of Alkenes via a Sulfinyl-Smiles Rearrangement and Vinylcyclopropane Ring-Opening Cascade.JACS Au · 2026Article
- Electroreductive Radical Olefin Difunctionalization with Fluorinated Gases Enabled by Dosage Delivery from a Metal-Organic Framework.Journal of the American Chemical Society · 2026Article
- Radical docking-migration: a powerful strategy for difunctionalization of alkenes and alkynes.Chemical science · 2026Review
- Chloroalkylation of Unactivated Alkenes via a Cobalt-Mediated Radical Ligand Transfer (RLT) Photoredox Catalysis Platform.JACS Au · 2025Article
- Bimolecular Homolytic Substitution (SACS central science · 2025Review
- Stilbenes in cancer therapy: insights into molecular targets, and advances towards clinical application.Medical oncology (Northwood, London, England) · 2025Review
- A Comprehensive Review of Radical-Mediated Intramolecular Cyano-Group Migration.Molecules (Basel, Switzerland) · 2025Review
- Organic Peroxides in Transition-Metal-Free Cyclization and Coupling Reactions (C-C) via Oxidative Transformation.ACS omega · 2025Review
- Copper-Catalyzed Selective Amino-alkoxycarbonylation of Unactivated Alkenes with CO.Journal of the American Chemical Society · 2025Article
- Radical-Mediated Trifunctionalization Reactions.Molecules (Basel, Switzerland) · 2024Review
- Radical Cyclization-Initiated Difunctionalization Reactions of Alkenes and Alkynes.Molecules (Basel, Switzerland) · 2024Review
- A free-radical design featuring an intramolecular migration for a synthetically versatile alkyl-(hetero)arylation of simple olefins.Chemical science · 2024Article
- Radical Reactions in Organic Synthesis: Exploring in-, on-, and with-Water Methods.Molecules (Basel, Switzerland) · 2024Review
- Modular access to alkylgermanes via reductive germylative alkylation of activated olefins under nickel catalysis.Nature communications · 2023Article
- Coordinating activation strategy enables 1,2-alkylamidation of alkynes.Chemical science · 2023Article
- Azido-alkynylation of alkenes through radical-polar crossover.Chemical science · 2023Article
- Atom-economic and stereoselective catalytic synthesis of fully substituted enol esters/carbonates of amides in acyclic systems enabled by boron Lewis acid catalysis.Chemical science · 2023Article
- Remote Radical 1,3-, 1,4-, 1,5-, 1,6- and 1,7-Difunctionalization Reactions.Molecules (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Popular and readily available alkenes and alkynes are good substrates for the preparation of functionalized molecules through radical and/or ionic addition reactions. Difunctionalization is a topic of current interest due to its high efficiency, substrate versatility, and operational simplicity. Presented in this article are radical addition followed by oxidation and nucleophilic addition reactions for difunctionalization of alkenes or alkynes. The difunctionalization could be accomplished through 1,2-addition (vicinal) and 1,n-addition (distal or remote) if H-atom or group-transfer is involved in the reaction process. A wide range of moieties, such as alkyl (R), perfluoroalkyl (R
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.