ReviewInternational journal of molecular sciences2020
Oxygen Transport during Ex Situ Machine Perfusion of Donor Livers Using Red Blood Cells or Artificial Oxygen Carriers.
Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 47 citations in OpenAlex.
- Dual acellular subnormothermic machine perfusion for enhanced uterus preservation in a swine model.Acta obstetricia et gynecologica Scandinavica · 2026Article
- Article
- Comparison of Normothermic and Subnormothermic Machine Perfusion of Porcine Kidneys Using a Novel Fully Synthetic Perfusion Solution: A Proof-of-Concept Study.Journal of clinical medicine · 2026Article
- Time as a Therapeutic Ally: The Promise of Long-Term Solid Organ and Tissue Perfusion.Transplant international : official journal of the European Society for Organ Transplantation · 2026Review
- Perfusion Pressures and Weight Loss During Normothermic Machine Perfusion of Human Donor Livers.Artificial organs · 2025Observational
- Organ preservation: current limitations and optimization approaches.Frontiers in medicine · 2025Review
- Establishing a Swine Model to Study Uterus Dynamic Preservation and Transplantation.Journal of visualized experiments : JoVE · 2024Article
- Continuous oxygen monitoring to enhance ex-vivo organ machine perfusion and reconstructive surgery.Biosensors & bioelectronics · 2024Article
- [Machine perfusion in transplantation surgery].Chirurgie (Heidelberg, Germany) · 2024Review
- Subnormothermic Oxygenated Machine Perfusion (24 h) in DCD Kidney Transplantation.Transplantation direct · 2024Article
- Gradual rewarming with a hemoglobin-based oxygen carrier improves viability of donation after circulatory death in rat livers.Frontiers in transplantation · 2024Article
- Real-time monitoring of mitochondrial oxygenation during machine perfusion using resonance Raman spectroscopy predicts organ function.Research square · 2023Article
- Newly developed gas-assisted sonodynamic therapy in cancer treatment.Acta pharmaceutica Sinica. B · 2023Review
- Oxygen Nanocarriers for Improving Cardioplegic Solution Performance: Physico-Chemical Characterization.International journal of molecular sciences · 2023Article
- Vitrification and nanowarming enable long-term organ cryopreservation and life-sustaining kidney transplantation in a rat model.Nature communications · 2023Article
- Intermittent Surface Oxygenation Results in Similar Mitochondrial Protection and Maintenance of Aerobic Metabolism as Compared to Continuous Oxygenation during Hypothermic Machine Kidney Machine Perfusion.Journal of clinical medicine · 2023Article
- Biocompatibility of the oxygen carrier polymerized human hemoglobin towards HepG2/C3A cells.Heliyon · 2023Article
- Current Evidence and Future Perspectives to Implement Continuous and End-Ischemic Use of Normothermic and Oxygenated Hypothermic Machine Perfusion in Clinical Practice.Journal of clinical medicine · 2023Review
- Oxygen-carrying sequential preservation mitigates liver grafts ischemia-reperfusion injury.iScience · 2023Article
- Oxygen carriers affect kidney immunogenicity duringFrontiers in transplantation · 2023Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxygenated ex situ machine perfusion of donor livers is an alternative for static cold preservation that can be performed at temperatures from 0 °C to 37 °C. Organ metabolism depends on oxygen to produce adenosine triphosphate and temperatures below 37 °C reduce the metabolic rate and oxygen requirements. The transport and delivery of oxygen in machine perfusion are key determinants in preserving organ viability and cellular function. Oxygen delivery is more challenging than carbon dioxide removal, and oxygenation of the perfusion fluid is temperature dependent. The maximal oxygen content of water-based solutions is inversely related to the temperature, while cellular oxygen demand correlates positively with temperature. Machine perfusion above 20 °C will therefore require an oxygen carrier to enable sufficient oxygen delivery to the liver. Human red blood cells are the most physiological oxygen carriers. Alternative artificial oxygen transporters are hemoglobin-based oxygen carriers, perfluorocarbons, and an extracellular oxygen carrier derived from a marine invertebrate. We describe the principles of oxygen transport, delivery, and consumption in machine perfusion for donor livers using different oxygen carrier-based perfusion solutions and we discuss the properties, advantages, and disadvantages of these carriers and their use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.