Evidence map›Paper›PMID 33379356›Full record

ArticleInternational journal of molecular sciences2020

Y-Box Binding Protein-1 Promotes Epithelial-Mesenchymal Transition in Sorafenib-Resistant Hepatocellular Carcinoma Cells.

Li-Zhu Liao, Chih-Ta Chen, Nien-Chen Li, Liang-Chun Lin, Bo-Shih Huang, Ya-Hui Chang, Lu-Ping Chow

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Li-Zhu LiaoGraduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei 100233, Taiwan.
Chih-Ta ChenGraduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei 100233, Taiwan.
Nien-Chen LiGraduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei 100233, Taiwan.
Liang-Chun LinGraduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei 100233, Taiwan.ORCID 0000-0002-5219-5212
Bo-Shih HuangGraduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei 100233, Taiwan.
Ya-Hui ChangGraduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei 100233, Taiwan.
Lu-Ping ChowGraduate Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei 100233, Taiwan.
National Taiwan University · TW

Funding

Ministry of Science and Technology, Taiwan MOST 108-2320-B-002-025
6 · The paper itself

Abstract

Hepatocellular carcinoma is one of the most common cancer types worldwide. In cases of advanced-stage disease, sorafenib is considered the treatment of choice. However, resistance to sorafenib remains a major obstacle for effective clinical application. Based on integrated phosphoproteomic and The Cancer Genome Atlas (TCGA) data, we identified a transcription factor, Y-box binding protein-1 (YB-1), with elevated phosphorylation of Ser102 in sorafenib-resistant HuH-7

Indexed as

Drug Resistance, NeoplasmEpithelial-Mesenchymal TransitionAnimalsBiomarkers, TumorCarcinoma, Hepatocellularcdc42 GTP-Binding ProteinCell Line, TumorCell MovementCell ProliferationGene Expression Regulation, NeoplasticHumansLiver NeoplasmsMiceNeoplasm InvasivenessPhosphorylationPhosphoserineBiomarkers, Tumorcdc42 GTP-Binding ProteinPhosphoserineSorafenibY-Box-Binding Protein 1YBX1 protein, humandrug resistanceepithelial-mesenchymal transitionhepatocellular carcinoma cellS102 phosphorylationsorafenibYB-1

Identifiers

PMID33379356
PMCPMC7795419
OpenAlexW3117262306

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.