ArticleMolecules (Basel, Switzerland)2020
Synthesis, Photoisomerization, Antioxidant Activity, and Lipid-Lowering Effect of Ferulic Acid and Feruloyl Amides.
Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Antioxidant and free radical scavenging potential of feruloyl amino acids and dipeptide derivatives: an experimental and theoretical investigation.RSC advances · 2026Article
- Rhizobacteria-Induced Systemic Priming Against Fungal Pathogens Involves Hydroxycinnamic Acid Amides.Plant, cell & environment · 2026Article
- Multicomponent Hosomi-Sakurai reaction on chiral, bio-based, alcohols.RSC advances · 2025Article
- Design, synthesis, characterization of ferulic acid andPharmaceutical science advances · 2024Article
- Ferulic Acid Alleviates Lipid and Bile Acid Metabolism Disorders by Targeting FASN and CYP7A1 in Iron Overload-Treated Mice.Antioxidants (Basel, Switzerland) · 2024Article
- Article
- Dietary Polyphenols: Review on Chemistry/Sources, Bioavailability/Metabolism, Antioxidant Effects, and Their Role in Disease Management.Antioxidants (Basel, Switzerland) · 2024Review
- Green Extraction and Preliminary Biological Activity of Hydrolyzed Collagen Peptides (HCPs) Obtained from Whole Undersized Unwanted Catches (Molecules (Basel, Switzerland) · 2023Article
- Design, synthesis, antiviral activities of ferulic acid derivatives.Frontiers in pharmacology · 2023Article
- Protective Effects of Ferulic Acid on Metabolic Syndrome: A Comprehensive Review.Molecules (Basel, Switzerland) · 2022Review
- Biomimetic Enzymatic Oxidative Coupling of Barley Phenolamides: Hydroxycinnamoylagmatines.Journal of agricultural and food chemistry · 2022Article
- First Evidence of Anti-Steatotic Action of Macrotympanain A1, an Amphibian Skin Peptide fromMolecules (Basel, Switzerland) · 2022Article
- Herbal therapy for ameliorating nonalcoholic fatty liver disease via rebuilding the intestinal microecology.Chinese medicine · 2021Review
- Antioxidant and Antisteatotic Activities of Fucoidan Fractions from Marine and Terrestrial Sources.Molecules (Basel, Switzerland) · 2021Article
- Characterization of Feruloyl Esterase fromFoods (Basel, Switzerland) · 2021Article
- Antioxidant and Antisteatotic Activities of a New Fucoidan Extracted fromMolecules (Basel, Switzerland) · 2021Article
- The Potential Antioxidant Activity and Characterization of Bioactive Compounds ofBioMed research international · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Ugi four-component reaction employing naturally occurred ferulic acid (FA) is proposed as a convenient method to synthesize feruloyl tertiary amides. Applying this strategy, a peptoid-like derivative of ferulic acid (FEF77) containing 2 additional hydroxy-substituted aryl groups, has been synthesized. The influence of the configuration of the double bond of ferulic acid and feruloyl amide on the antioxidant activity has been investigated thanks to light-mediated isomerization studies. At the cellular level, both FA, trans and cis isomers of FEF77 were able to protect human endothelial cord vein (HECV) cells from the oxidative damage induced by exposure to hydrogen peroxide, as measured by cell viability and ROS production assays. Moreover, in steatotic FaO rat hepatoma cells, an in vitro model resembling non-alcoholic fatty liver disease (NAFLD), the molecules exhibited a lipid-lowering effect, which, along with the antioxidant properties, points to consider feruloyl amides for further investigations in a therapeutic perspective.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.