ReviewInternational journal of molecular sciences2020
From Obesity to Hippocampal Neurodegeneration: Pathogenesis and Non-Pharmacological Interventions.
Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed.
- Obesity-related differences in amygdala and hippocampal volume and metabolism before and after a placebo-controlled antidepressant trial in major depressive disorder.Scientific reports · 2026Trial
- Disturbed Spatial Learning and Hippocampal Molecular and Histological Alterations in Middle-Aged Rats with a History of Polycystic Ovary Syndrome.International journal of endocrinology and metabolism · 2027Article
- High-Intensity Interval Training Ameliorates High-Fat Diet-Induced Cognitive Impairment and Is Associated with Altered Adipokine Signaling in the Olfactory Bulb and Hippocampus.Molecular neurobiology · 2026Article
- Atorvastatin Exerts Context-Dependent Metabolic and Beneficial Effects on Behavior and Apoptotic Signaling in a Cafeteria Diet-Induced Metabolic Dysfunction Model.Neurochemical research · 2026Article
- Green tea catechin EGCG attenuates hippocampal atrophy and cognitive impairment in obesity via autophagy signaling.NPJ science of food · 2026Article
- Endurance training mitigates obesity-induced hippocampal impairment by enhancing neurotrophin signalling, synaptic plasticity, and cellular responses in a female rat model.IBRO neuroscience reports · 2026Article
- Deciphering the obesity paradox in phenotypic age acceleration through thyroid hormone sensitivity: results from NHANES 2007-2010.Hormones (Athens, Greece) · 2026Article
- Obesity supersizes macrophage and neutrophil activation after stroke while lipid droplets play a protective role.Journal of neuroinflammation · 2026Article
- Varietal Differences in Kidney Beans Modulate Gut Microbiota and Inflammation During High-Fat Diet-Induced Obesity in Male Mice.Nutrients · 2026Article
- Adipose Tissue and Central Nervous System Crosstalk: Roles in Pain and Cognitive Dysfunction.Biomedicines · 2025Review
- Chronic exercise reduces astrocytic c-Fos and CCL2 via conditioned serum and cerebrospinal fluid.Narra J · 2025Article
- Protective effects of Parabacteroides distasonis against high-fat diet-induced brain injury in mice.NPJ science of food · 2025Article
- Visceral adipose tissue-derived extracellular vesicles promote stress susceptibility in obese mice via miR-140-5p.Acta pharmacologica Sinica · 2025Article
- Obesity accelerates age-related memory deficits and alters white matter tract integrity in Ldlr-/-.Leiden mice.Brain, behavior, & immunity - health · 2025Article
- Effects of Sleep-Disordered Breathing on Daytime Brain Activity in Community-Dwelling Older Adults.Sleep science (Sao Paulo, Brazil) · 2025Article
- Special Issue "Adipose Tissue Diseases: Physiopathology, Molecular Mechanism, Diagnosis, and Treatment".International journal of molecular sciences · 2025Article
- Impact of visceral adiposity index on cognitive impairment and cognitive trajectories in Chinese middle-aged and older adults.Frontiers in public health · 2025Article
- Perspectives on obesity imaging: [International journal of obesity (2005) · 2025Article
- The Hidden Dangers of Sedentary Living: Insights into Molecular, Cellular, and Systemic Mechanisms.International journal of molecular sciences · 2024Review
- Combination of Gold Nanoparticles with Carnitine Attenuates Brain Damage in an Obesity Animal Model.Molecular neurobiology · 2024Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
High-caloric diet and physical inactivity predispose individuals to obesity and diabetes, which are risk factors of hippocampal neurodegeneration and cognitive deficits. Along with the adipose-hippocampus crosstalk, chronically inflamed adipose tissue secretes inflammatory cytokine could trigger neuroinflammatory responses in the hippocampus, and in turn, impairs hippocampal neuroplasticity under obese and diabetic conditions. Hence, caloric restriction and physical exercise are critical non-pharmacological interventions to halt the pathogenesis from obesity to hippocampal neurodegeneration. In response to physical exercise, peripheral organs, including the adipose tissue, skeletal muscles, and liver, can secret numerous exerkines, which bring beneficial effects to metabolic and brain health. In this review, we summarized how chronic inflammation in adipose tissue could trigger neuroinflammation and hippocampal impairment, which potentially contribute to cognitive deficits in obese and diabetic conditions. We also discussed the potential mechanisms underlying the neurotrophic and neuroprotective effects of caloric restriction and physical exercise by counteracting neuroinflammation, plasticity deficits, and cognitive impairments. This review provides timely insights into how chronic metabolic disorders, like obesity, could impair brain health and cognitive functions in later life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.