Evidence map›Paper›PMID 33379137›Full record

ArticleBiosensors2020

Potentiometric Biosensing of Ascorbic Acid, Uric Acid, and Cysteine in Microliter Volumes Using Miniaturized Nanoporous Gold Electrodes.

Christopher J Freeman, Borkat Ullah, Md Shafiul Islam, Maryanne M Collinson

Open access · goldAbstract read
In one paragraph

Article in Biosensors, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Christopher J FreemanDepartment of Chemistry and Biochemistry, Old Dominion University, Norfolk, VA 23529, USA.ORCID 0000-0001-9344-8207
Borkat UllahDepartment of Chemistry, Virginia Commonwealth University, Richmond, VA 23284, USA.ORCID 0000-0002-9317-7379
Md Shafiul IslamDepartment of Chemistry, Virginia Commonwealth University, Richmond, VA 23284, USA.
Maryanne M CollinsonDepartment of Chemistry, Virginia Commonwealth University, Richmond, VA 23284, USA.ORCID 0000-0001-6839-5334
Virginia Commonwealth University · USOld Dominion University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Potentiometric redox sensing is a relatively inexpensive and passive approach to evaluate the overall redox state of complex biological and environmental solutions. The ability to make such measurements in ultra-small volumes using high surface area, nanoporous electrodes is of particular importance as such electrodes can improve the rates of electron transfer and reduce the effects of biofouling on the electrochemical signal. This work focuses on the fabrication of miniaturized nanoporous gold (NPG) electrodes with a high surface area and a small footprint for the potentiometric redox sensing of three biologically relevant redox molecules (ascorbic acid, uric acid, and cysteine) in microliter volumes. The NPG electrodes were inexpensively made by attaching a nanoporous gold leaf prepared by dealloying 12K gold in nitric acid to a modified glass capillary (1.5 mm id) and establishing an electrode connection with copper tape. The surface area of the electrodes was ~1.5 cm

Indexed as

Biosensing TechniquesAscorbic AcidCysteineElectrochemical TechniquesElectrodesGoldNanoporesPorosityUric AcidAscorbic AcidCysteineGoldUric AcidNernst equationopen-circuit potentialoxidation reduction potential (ORP)potentiometryredox potential

Identifiers

PMID33379137
PMCPMC7823660
OpenAlexW3114625268

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.