Evidence map›Paper›PMID 33378746›Full record

ArticleAging2020

The effects of early-life growth hormone intervention on tissue specific histone H3 modifications in long-lived Ames dwarf mice.

Fang Zhang, Mert Icyuz, Andrzej Bartke, Liou Y Sun

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Early Life Interventions Can Shape Aging.Frontiers in endocrinology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Fang ZhangDepartment of Biology, University of Alabama at Birmingham, Birmingham, AL 35254, USA.
Mert IcyuzDepartment of Biology, University of Alabama at Birmingham, Birmingham, AL 35254, USA.
Andrzej BartkeDepartment of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL 62702, USA.
Liou Y SunDepartment of Biology, University of Alabama at Birmingham, Birmingham, AL 35254, USA.
University of Alabama at Birmingham · USSouthern Illinois University School of Medicine · US

Funding

Longevity assurance interventions, metabolic health and Alzheimer's DiseaseR01AG057734 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SUN, LIOU · 2018 to 2022
$2.5M
The effects of early life nutritional and hormonal signals on mammalian aging (Health Disparities Admin Supp)K01AG048264 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SUN, LIOU · 2014 to 2018
$784k
Aging and Somatotropic axis and Abeta toxicityR21AG050225 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SUN, LIOU · 2017 to 2018
$397k
Longevity assurance interventions, metabolic health and Aβ toxicityR56AG057734 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SUN, LIOU · 2017 to 2017
$366k
NIA NIH HHS K01 AG048264NIA NIH HHS R01 AG057734NIA NIH HHS R21 AG050225NIA NIH HHS R56 AG057734
6 · The paper itself

Abstract

Histone modifications, specifically in the lysine residues of histone H3, have been implicated in lifespan regulation in several model organisms. Our previous studies showed that growth hormone (GH) treatment during early life can dramatically influence lifespan in long-lived Ames dwarf mice. However, the effects of this hormonal intervention on epigenetic modifications have never been examined. In this study, we sought to compare tissue-specific histone H3 lysine methylation and acetylation markers in Ames dwarf and wild type (WT) mice and to determine how these markers are affected by early-life GH intervention. Ames dwarf mice exhibited suppressed H3K4me in both hepatic and brain tissues, while showing elevated H3K27me in the brain. Early-life GH intervention significantly altered the histone H3 markers in those tissues. Furthermore, early GH intervention increased expression of histone H3 acetylation at multiple lysine residues in a tissue-specific manner. This included changes in H3K14ac and H3K18ac in the liver and brain, H3K18ac in visceral adipose tissue and H3K9ac, H3K14ac and H3K27ac in subcutaneous adipose tissue. This study serves as an initial, but important step in elucidating the epigenetic mechanisms by which hormonal signals during early life can influence aging and longevity in mammals.

Indexed as

AcetylationAnimalsBrainDisease Models, AnimalDNA (Cytosine-5-)-Methyltransferase 1DNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNA Methyltransferase 3BDwarfism, PituitaryEnhancer of Zeste Homolog 2 ProteinEpigenesis, GeneticGrowth HormoneHistone CodeHistonesHomeodomain ProteinsHormone Replacement TherapyDNA (Cytosine-5-)-Methyltransferase 1DNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNA Methyltransferase 3BDnmt1 protein, mouseEnhancer of Zeste Homolog 2 ProteinEzh2 protein, mouseGrowth HormoneHistonesHomeodomain ProteinsProphet of Pit-1 proteinAmes dwarf miceDNA methylationgrowth hormonehistone H3 acetylationhistone H3 methylation

Identifiers

PMID33378746
PMCPMC7880366
OpenAlexW3113731946

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.