Evidence map›Paper›PMID 33378658›Full record

ReviewTrends in neurosciences2021

Computational Models of Interoception and Body Regulation.

Frederike H Petzschner, Sarah N Garfinkel, Martin P Paulus, Christof Koch, Sahib S Khalsa

Open access · greenAbstract readReview
In one paragraph

Review in Trends in neurosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 5 pooled it
15.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 5 syntheses or guidelines pooled it, 213 citations in OpenAlex.

  1. Pooled it
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  4. Pooled it
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  6. Trial
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  8. Heartbeat-evoked neural response abnormalities in generalized anxiety disorder during peripheral adrenergic stimulation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Trial
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  12. Observational
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  20. Insular cortex predictions regulate glucose homeostasis.bioRxiv : the preprint server for biology · 2025
    Article

36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Frederike H PetzschnerTranslational Neuromodeling Unit (TNU), Institute for Biomedical Engineering, University of Zurich, ETH Zurich, Switzerland. Electronic address: petzschner@biomed.ee.ethz.ch.
Sarah N GarfinkelDepartment of Neuroscience, Brighton and Sussex Medical School, University of Sussex, Falmer, UK; Sussex Partnership NHS Foundation Trust, Brighton, UK.
Martin P PaulusLaureate Institute for Brain Research, Tulsa, OK, USA; Oxley College of Health Sciences, University of Tulsa, Tulsa, OK, USA.
Christof KochAllen Institute for Brain Science, Seattle, WA, USA.
Sahib S KhalsaLaureate Institute for Brain Research, Tulsa, OK, USA; Oxley College of Health Sciences, University of Tulsa, Tulsa, OK, USA.
Tulsa Community College · USAllen Institute for Brain Science · USBrighton and Sussex Medical School · GBUniversity of Zurich · CH

Funding

The Center for Neuroscience-based Mental Health Assessment and Prediction (NEUROMAP)P20GM121312 · NIGMS · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI Jonathan Savitz · 2017 to 2026
$23.7M
Neural Basis of Meal Related Interoceptive Dysfunction in Anorexia NervosaK23MH112949 · NIMH · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI KHALSA, SAHIB · 2017 to 2021
$994k
NIGMS NIH HHS P20 GM121312NIMH NIH HHS K23 MH112949
6 · The paper itself

Abstract

To survive, organisms must effectively respond to the challenge of maintaining their physiological integrity in the face of an ever-changing environment. Preserving this homeostasis critically relies on adaptive behavior. In this review, we consider recent frameworks that extend classical homeostatic control via reflex arcs to include more flexible forms of adaptive behavior that take interoceptive context, experiences, and expectations into account. Specifically, we define a landscape for computational models of interoception, body regulation, and forecasting, address these models' unique challenges in relation to translational research efforts, and discuss what they can teach us about cognition as well as physical and mental health.

Indexed as

InteroceptionCognitionComputer SimulationForecastingHumansactive inferenceallostasiscomputational psychiatryhomeostasispredictive codingreinforcement learning

Identifiers

PMID33378658
PMCPMC8109616
OpenAlexW3114806425

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.