Evidence map›Paper›PMID 33378657›Full record

ReviewTrends in neurosciences2021

Interventions and Manipulations of Interoception.

Helen Y Weng, Jack L Feldman, Lorenzo Leggio, Vitaly Napadow, Jeanie Park, Cynthia J Price

Abstract readReview
In one paragraph

Review in Trends in neurosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

110 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  13. Article
  14. Review
  15. The priming effect of interoception on savoring positive emotion: An EEG study.Cognitive, affective & behavioral neuroscience · 2026
    Article
  16. The ventilatory response to arousal from sleep is elevated in young individuals with post-traumatic stress disorder symptoms.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026
    Article
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50 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Helen Y WengOsher Center for Integrative Medicine, University of California, San Francisco, San Francisco, CA, USA; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA. Electronic address: helen.weng@ucsf.edu.
Jack L FeldmanDepartment of Neurobiology, David Geffen School of Medicine, Center for Health Sciences, University of California at Los Angeles, Los Angeles, CA, USA.
Lorenzo LeggioClinical Psychoneuroendocrinology and Neuropsychopharmacology Section, Translational Addiction Medicine Branch, National Institute on Drug Abuse Intramural Research Program and National Institute on Alcohol Abuse and Alcoholism Division of Intramural Clinical and Biological Research, National Institutes of Health, Baltimore and Bethesda, MD, USA; Medication Development Program, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD, USA; Center for Alcohol and Addiction Studies, Department of Behavioral and Social Sciences, Brown University, Providence, RI, USA.
Vitaly NapadowMartinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, USA; Department of Anesthesiology, Brigham and Women's Hospital, Boston, MA, USA.
Jeanie ParkRenal Division, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA; Research Service Line, Department of Veterans Affairs Medical Center, Decatur, GA, USA.
Cynthia J PriceSchool of Nursing, University of Washington, Seattle, WA, USA; Osher Center for Integrative Medicine, University of Washington, Seattle, WA, USA.

Funding

Clinical Psychoneuroendocrinology and Neuropsychopharmacology (CPN)ZIAAA000218 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI LEGGIO, LORENZO · 2013 to 2020
$22.8M
Clinical Psychoneuroendocrinology and Neuropsychopharmacology (CPN)ZIADA000635 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI LEGGIO, LORENZO · 2020 to 2025
$15.2M
Core NIBSP01AT009965 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2018 to 2023
$10.9M
Neural control of breathingR35HL135779 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FELDMAN, JACK L · 2017 to 2023
$5.6M
Neurovascular Regulation During Exercise In Humans With Chronic Kidney DiseaseR01HL135183 · NHLBI · EMORY UNIVERSITY · PI Jeanie Park · 2017 to 2026
$5.4M
Functional Dissection of Medullary Respiratory MicrocircuitsR01NS072211 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FELDMAN, JACK L · 2010 to 2020
$3.8M
Mapping the linkage between auricular vagus nerve receptors and cardiovagal modulationOT2OD023867 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI NAPADOW, VITALY · 2016 to 2021
$3.4M
Mindful Body Awareness Training as an Adjunct to Medication Assisted Treatment for Opioid Use Disorder: An ancillary studyR01AT010742 · NCCIH · UNIVERSITY OF WASHINGTON · PI MERRILL, JOSEPH O, PRICE, CYNTHIA J · 2019 to 2022
$2.4M
Mindful Body Awareness Training as an Adjunct to Medication Assisted Treatment for Opioid Use DisorderR33AT009932 · NCCIH · UNIVERSITY OF WASHINGTON · PI PRICE, CYNTHIA J · 2019 to 2021
$2.1M
Sympatho-inhibition with Mindfulness in Chronic Kidney DiseaseR61AT010457 · NCCIH · EMORY UNIVERSITY · PI PARK, JEANIE · 2019 to 2020
$946k
Optimizing measurement of mindfulness meditation using brain pattern classification.K08AT009385 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WENG, HELEN Y · 2017 to 2020
$784k
Neural-Physiology Biosignature Shared across Negative Valence and Arousal DomainsR21MH103468 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI GOLDSTEIN, JILL M, NAPADOW, VITALY · 2014 to 2015
$482k
CSRD VA I01 CX001065Intramural NIH HHS ZIA AA000218Intramural NIH HHS ZIA DA000635NCCIH NIH HHS K08 AT009385NCCIH NIH HHS P01 AT009965NCCIH NIH HHS R01 AT010742NCCIH NIH HHS R21 AT009034NCCIH NIH HHS R33 AT009932NCCIH NIH HHS R61 AT010457NHLBI NIH HHS R01 HL135183NHLBI NIH HHS R35 HL135779NIDDK NIH HHS R21 DK116029NIH HHS OT2 OD023867NIMH NIH HHS R21 MH103468NINDS NIH HHS R01 NS072211
6 · The paper itself

Abstract

Interoceptive pathways may be manipulated at various levels to develop interventions to improve symptoms in a range of disorders. Primarily through the lens of the respiratory system, we outline various pathways that can be manipulated at neural, behavioral, and psychological levels to change the representation of and attention to interoceptive signals, which can alter interconnected physiological systems and improve functioning and adaptive behavior. Interventions can alter interoception via neuromodulation of the vagus nerve, slow breathing to change respiratory rate and depth, or awareness processes such as mindfulness-based interventions. Aspects of this framework may be applied to other physiological systems and future research may integrate interventions across multiple levels of manipulation or bodily systems.

Indexed as

InteroceptionMindfulnessAwarenessHumansinteroceptive awarenessmindfulnessneuromodulationPTSDrespirationsubstance use disorder

Identifiers

PMID33378657
PMCPMC7805576

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.