Evidence map›Paper›PMID 33378654›Full record

ReviewTrends in neurosciences2021

Functions of Interoception: From Energy Regulation to Experience of the Self.

Karen S Quigley, Scott Kanoski, Warren M Grill, Lisa Feldman Barrett, Manos Tsakiris

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in neurosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

124 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  11. Categorization is 'baked' into the brain.Nature reviews. Neuroscience · 2026
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64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Karen S QuigleyDepartment of Psychology, Northeastern University, Boston, MA, USA; Edith Nourse Rogers Memorial VA Hospital, Bedford, MA, USA. Electronic address: k.quigley@northeastern.edu.
Scott KanoskiDepartment of Biological Sciences, University of Southern California, Los Angeles, CA, USA.
Warren M GrillDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Lisa Feldman BarrettDepartment of Psychology, Northeastern University, Boston, MA, USA; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Manos TsakirisDepartment of Psychology, Royal Holloway, University of London, London, UK; Department of Behavioural and Cognitive Sciences, Faculty of Humanities, Education and Social Sciences, University of Luxembourg, Luxembourg.

Funding

Affect regulation and Beta Amyloid: Maturational Factors in Aging and Age-Related PathologyR01MH113234 · NIMH · NORTHEASTERN UNIVERSITY · PI DICKERSON, BRADFORD C, ISAACOWITZ, DEREK M · 2017 to 2021
$4.2M
Fundamental subcortical mechanisms of affective processingU01CA193632 · NCI · NORTHEASTERN UNIVERSITY · PI BARRETT, LISA FELDMAN, SATPUTE, AJAY · 2016 to 2020
$3.0M
NCI NIH HHS U01 CA193632NIMH NIH HHS R01 MH113234
6 · The paper itself

Abstract

We review recent work on the functions of interoceptive processing, by which the nervous system anticipates, senses, and integrates signals originating from the body. We focus on several exemplar functions of interoception, including energy regulation (ingestion and excretion), memory, affective and emotional experience, and the psychological sense of self. We emphasize two themes across these functions. First, the anatomy of interoceptive afferents makes it difficult to manipulate or directly measure interoceptive signaling in humans. Second, recent evidence shows that multimodal integration occurs across interoceptive modalities and between interoceptive and exteroceptive modalities. Whereas exteroceptive multimodal integration has been studied relatively extensively, fundamental questions remain regarding multimodal integration that involves interoceptive modalities. Future empirical work is required to better understand how and where multimodal interoceptive integration occurs.

Indexed as

InteroceptionEmotionsHumansallostasisfeedingmemorypsychological sense of selfurinary function

Identifiers

PMID33378654
PMCPMC7780233

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.