ArticleCell2021
NeuroPAL: A Multicolor Atlas for Whole-Brain Neuronal Identification in C. elegans.
Article in Cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 178 papers.
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Who cites it
178 citing papers in PubMed, 310 citations in OpenAlex.
- Targeted integration of extrachromosomal arrays inScience advances · 2026Article
- Regulatory architecture controlling terminal differentiation of an interoceptive paraneuron in Caenorhabditis elegans.Development (Cambridge, England) · 2026Article
- Intrinsic and non-cell-autonomous roles for the neurodevelopmental syndrome-linked transcription factor UNC-3/EBF.Nature communications · 2026Article
- Neuronal Nrf/SKN-1B controls a sexually dimorphic neuroendocrine pathway for C. elegans exploratory behaviour.PLoS genetics · 2026Article
- Cohesin and NuRD antagonistically drive alternative neuronal fates via PLZF transcription factors.Science advances · 2026Article
- Mechanosensory encoding of surface mechanics optimizes locomotion.Nature communications · 2026Article
- Neuronal RNAi and oxygen-sensing circuit shape germline resilience to heat stress.Current biology : CB · 2026Article
- Regulatory architecture controlling terminal differentiation of an interoceptive paraneuron inbioRxiv : the preprint server for biology · 2026Article
- Article
- Analysis of Nematode Ventral Nerve Cords Suggests Multiple Instances of Evolutionary Changes to Neuron Number.Evolution & development · 2026Article
- Neural sequences underlying directed turning in Caenorhabditis elegans.Nature neuroscience · 2026Article
- Optimization of connectome weights for a neural network model generating both forward and backward locomotion in C. elegans.Scientific reports · 2026Article
- Tunable tau expression in C. elegans neurons reveals that early-AD tau phosphorylation selectively impacts behavior and mitochondrial quality control.Neurobiology of disease · 2026Article
- Cohesin and NuRD Antagonistically Drive Alternative Neuronal Fates via PLZF Transcription Factors.bioRxiv : the preprint server for biology · 2026Article
- A panoramic view of the expression and function of the Doublesex/DMRT gene family inScience advances · 2026Article
- Interlocked transcription factor feedback loops maintain and restore adult touch sensation.Cell reports · 2026Article
- Whole-organism spatial transcriptomics at single-cell resolution inbioRxiv : the preprint server for biology · 2026Article
- A conserved C. elegans zinc finger homeodomain protein, ZFH-2, is continuously required for the structural integrity and function of the alimentary tract and gonad.Development (Cambridge, England) · 2026Article
- Maternal age modulates progeny social behavior via a small RNA-neuropeptide axis.bioRxiv : the preprint server for biology · 2026Article
- Compact Spectral Encoding Microscopy by Terrace Grating Optics.ACS photonics · 2026Article
118 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Comprehensively resolving neuronal identities in whole-brain images is a major challenge. We achieve this in C. elegans by engineering a multicolor transgene called NeuroPAL (a neuronal polychromatic atlas of landmarks). NeuroPAL worms share a stereotypical multicolor fluorescence map for the entire hermaphrodite nervous system that resolves all neuronal identities. Neurons labeled with NeuroPAL do not exhibit fluorescence in the green, cyan, or yellow emission channels, allowing the transgene to be used with numerous reporters of gene expression or neuronal dynamics. We showcase three applications that leverage NeuroPAL for nervous-system-wide neuronal identification. First, we determine the brainwide expression patterns of all metabotropic receptors for acetylcholine, GABA, and glutamate, completing a map of this communication network. Second, we uncover changes in cell fate caused by transcription factor mutations. Third, we record brainwide activity in response to attractive and repulsive chemosensory cues, characterizing multimodal coding for these stimuli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.