ArticleThe New England journal of medicine2021
Microvascular Injury in the Brains of Patients with Covid-19.
Registry-linked trialAbstract readLetter
In one paragraph
Article in The New England journal of medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04853836 (Olfactory Disfunction After COVID-19), which is not on this map. Cited by 352 papers, 7 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
352citing papers in PubMed, 7 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Olfactory Disfunction After COVID-19: Conventional Therapy Versus Intervention Treatment With Co-ultraPEALut
Who cites it
352 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Prevalence and long-term outcomes of brain fog and cognitive impairment in individuals with long COVID: A systematic review.Medicine · 2026Pooled it
- Metabolic brain changes in post-acute COVID-19: systematic review and meta-analysis of [18F]-FDG-PET findings.Brain structure & function · 2025Pooled it
- The global prevalence of depression, anxiety, and sleep disorder among patients coping with Post COVID-19 syndrome (long COVID): a systematic review and meta-analysis.BMC psychiatry · 2024Pooled it
- SARS-Cov-2 infection and neuropathological findings: a report of 18 cases and review of the literature.Acta neuropathologica communications · 2023Pooled it
- Pooled it
- Genetics of COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome: a systematic review.Annals of clinical and translational neurology · 2022Pooled it
- Sequelae of COVID-19 among previously hospitalized patients up to 1 year after discharge: a systematic review and meta-analysis.Infection · 2022Pooled it
- Trajectories of Inflammatory Markers and Post-COVID-19 Cognitive Symptoms: A Secondary Analysis of the CONTAIN COVID-19 Randomized Trial.Neurology(R) neuroimmunology & neuroinflammation · 2024Trial
- SARS-CoV-2 nucleocapsid induces hyperinflammation and vascular leakage through the Toll-like receptor signaling axis in macrophages.Science advances · 2026Article
- Neurological impairment in long COVID: implications for neurodegenerative disease.Journal of translational medicine · 2026Review
- Vascular inflammation in neuropsychiatric long COVID.Brain, behavior, & immunity - health · 2026Article
- Investigation of BOLD signal intensities in long COVID patients using 7T functional MRI.Brain, behavior, & immunity - health · 2026Article
- The lung-brain axis in neurodegeneration: inflammatory, immune, and vascular mechanisms with therapeutic implications.Inflammopharmacology · 2026Review
- Review
- The lung-brain axis: elucidating the mechanisms of pulmonary-driven neurological disorders.Journal of neuroinflammation · 2026Review
- Viral modulation of synaptic pruning: implications for neuropathology and brain function.Journal of virology · 2026Review
- Combination antiviral and anti-inflammatory therapy mitigates persistent neurological deficits in mice post SARS-CoV-2 infection.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Mechanisms and impact of long COVID: pathophysiology, neuropsychiatric effects and vaccination.Frontiers in immunology · 2026Review
- Impact of COVID-19 on new pharmacotherapy for insomnia: A matched cohort study using the national insurance claims database in Japan.PloS one · 2026Article
- Proteasomal inhibition compromises microvascular integrity via distinct effects on non-immune endothelial cells and immune cells.Frontiers in immunology · 2026Article
292 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
18 authors.
Myoung-Hwa LeeNational Institute of Neurological Disorders and Stroke, Bethesda, MD.
Daniel P PerlUniformed Services University of the Health Sciences, Bethesda, MD.
Govind NairNational Institute of Neurological Disorders and Stroke, Bethesda, MD.
Wenxue LiNational Institute of Neurological Disorders and Stroke, Bethesda, MD.
Dragan MaricNational Institute of Neurological Disorders and Stroke, Bethesda, MD.
Helen MurrayNational Institute of Neurological Disorders and Stroke, Bethesda, MD.
Stephen J DoddNational Institute of Neurological Disorders and Stroke, Bethesda, MD.
Alan P KoretskyNational Institute of Neurological Disorders and Stroke, Bethesda, MD.
Jason A WattsUniversity of Michigan, Ann Arbor, MI.
Vivian CheungUniversity of Michigan, Ann Arbor, MI.
Eliezer MasliahNational Institute on Aging, Bethesda, MD.
Iren Horkayne-SzakalyDefense Health Agency, Silver Spring, MD.
Robert JonesDefense Health Agency, Silver Spring, MD.
Michelle N StramOffice of Chief Medical Examiner, New York, NY.
Joel MoncurDefense Health Agency, Silver Spring, MD.
Marco HeftiUniversity of Iowa, Iowa City, IA.
Rebecca D FolkerthOffice of Chief Medical Examiner, New York, NY.
Avindra NathNational Institute of Neurological Disorders and Stroke, Bethesda, MD natha@ninds.nih.gov.ORCID 0000-0003-0927-5855
Funding
Neuropathogenesis of Retroviral InfectionsZIANS003130 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI NATH, AVINDRA · 2011 to 2025
$73.7MMRI contrast for molecular and cellular imaging of the brainZIANS003047 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI KORETSKY, ALAN · 2009 to 2025
$29.3MNeuroimmune responses and therapeutics of alpha-synucleinopathies of the aging populationZIAAG000936 · NIA · NATIONAL INSTITUTE ON AGING · PI COOKSON, MARK · 2017 to 2025
$4.1MThe University of Iowa Clinical and Translational Science AwardKL2TR002536 · NCATS · UNIVERSITY OF IOWA · PI BASSUK, ALEXANDER G · 2018 to 2022
$3.3MNovel tau-based diagnostics for neonatal hypoxic-ischemic injuryK23NS109284 · NINDS · UNIVERSITY OF IOWA · PI HEFTI, MARCO MATTHIAS · 2019 to 2023
$950kNCATS NIH HHS KL2 TR002536NINDS NIH HHS Division of Intramural ResearchNINDS NIH HHS K23 NS109284
Abstract
PubMed holds no abstract for this paper.
Indexed as
AutopsyBrainCOVID-19HumansMagnetic Resonance ImagingMicrovesselsMiddle AgedSARS-CoV-2
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT04853836ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.