Evidence map›Paper›PMID 33378601›Full record

SynthesisReviews in medical virology2021

The virome in early life and childhood and development of islet autoimmunity and type 1 diabetes: A systematic review and meta-analysis of observational studies.

Clare L Faulkner, Yi Xuan Luo, Sonia Isaacs, William D Rawlinson, Maria E Craig, Ki Wook Kim

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Reviews in medical virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Gut virome in early life: origins and implications.Current opinion in virology · 2022
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Clare L FaulknerSchool of Women's and Children's Health, University of New South Wales Faculty of Medicine, Sydney, New South Wales, Australia.
Yi Xuan LuoSchool of Women's and Children's Health, University of New South Wales Faculty of Medicine, Sydney, New South Wales, Australia.
Sonia IsaacsSchool of Women's and Children's Health, University of New South Wales Faculty of Medicine, Sydney, New South Wales, Australia.
William D RawlinsonSchool of Women's and Children's Health, University of New South Wales Faculty of Medicine, Sydney, New South Wales, Australia.ORCID 0000-0001-9238-0546
Maria E CraigSchool of Women's and Children's Health, University of New South Wales Faculty of Medicine, Sydney, New South Wales, Australia.ORCID 0000-0001-6004-576X
Ki Wook KimSchool of Women's and Children's Health, University of New South Wales Faculty of Medicine, Sydney, New South Wales, Australia.ORCID 0000-0001-9579-6408
New South Wales Department of Health · AUThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Viruses are postulated as primary candidate triggers of islet autoimmunity (IA) and type 1 diabetes (T1D), based on considerable epidemiological and experimental evidence. Recent studies have investigated the association between all viruses (the 'virome') and IA/T1D using metagenomic next-generation sequencing (mNGS). Current associations between the early life virome and the development of IA/T1D were analysed in a systematic review and meta-analysis of human observational studies from Medline and EMBASE (published 2000-June 2020), without language restriction. Inclusion criteria were as follows: cohort and case-control studies examining the virome using mNGS in clinical specimens of children ≤18 years who developed IA/T1D. The National Health and Medical Research Council level of evidence scale and Newcastle-Ottawa scale were used for study appraisal. Meta-analysis for exposure to specific viruses was performed using random-effects models, and the strength of association was measured using odds ratios (ORs) and 95% confidence intervals (CIs). Eligible studies (one case-control, nine nested case-control) included 1,425 participants (695 cases, 730 controls) and examined IA (n = 1,023) or T1D (n = 402). Meta-analysis identified small but significant associations between IA and number of stool samples positive for all enteroviruses (OR 1.14, 95% CI 1.00-1.29, p = 0.05; heterogeneity χ

Indexed as

AutoimmunityDiabetes Mellitus, Type 1ChildHigh-Throughput Nucleotide SequencingHumansInfantProspective StudiesViromechildhoodislet autoimmunitynext-generation sequencingtype 1 diabetesvirome

Identifiers

PMID33378601
PMCPMC8518965
OpenAlexW3114729896

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.