Evidence map›Paper›PMID 33378562›Full record

ArticleJournal of viral hepatitis2021

Proton pump inhibitor usage reduces sustained viral response rates for veterans with HIV/HCV coinfection on ledipasvir/sofosbuvir: a real-world study from a multicentre VA cohort.

Tzu-Hao Lee, Austin Chan, William Bryan, Lawrence Park, Mohamed Hashem, Mary Townsend, Cynthia Moylan, Rachel Britt, Steve Choi, Susanna Naggie

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Journal of viral hepatitis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Tzu-Hao LeeDivision of Gastroenterology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0002-2478-3447
Austin ChanDepartment of Medicine, Morehouse School of Medicine, Atlanta, GA, USA.
William BryanDurham Veterans Affairs Health Care System, Durham, NC, USA.
Lawrence ParkDurham Veterans Affairs Health Care System, Durham, NC, USA.
Mohamed HashemDurham Veterans Affairs Health Care System, Durham, NC, USA.
Mary TownsendDurham Veterans Affairs Health Care System, Durham, NC, USA.
Cynthia MoylanDivision of Gastroenterology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Rachel BrittDurham Veterans Affairs Health Care System, Durham, NC, USA.
Steve ChoiDivision of Gastroenterology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.
Susanna NaggieDurham Veterans Affairs Health Care System, Durham, NC, USA.
Duke University · USDurham VA Health Care System · USMorehouse School of Medicine · US

Funding

Social and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI GEORGIA Doris TOMARAS · 2005 to 2026
$50.5M
NIAID NIH HHS P30 AI064518
6 · The paper itself

Abstract

Previous studies have reported an association of proton pump inhibitor (PPI) use and decreased sustained viral response rate (SVR) in patients taking ledipasvir/sofosbuvir (LDV/SOF). The relationship between PPI usage and SVR is less clear in patients with HIV/HCV coinfection, where concomitant antiretrovirals may result in more complex drug interactions. This retrospective study evaluates the effects of acid suppression medications (PPI or H

Indexed as

CoinfectionHepatitis CHIV InfectionsVeteransAntiviral AgentsBenzimidazolesDrug Therapy, CombinationFluorenesHepacivirusHumansProton Pump InhibitorsRetrospective StudiesSofosbuvirTreatment OutcomeAntiviral AgentsBenzimidazolesFluorenesledipasvirProton Pump InhibitorsSofosbuvirHCVHIVledipasvirproton pump inhibitorsofosbuvir

Identifiers

PMID33378562
PMCPMC8054484
OpenAlexW3115527440

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.