Observational studyThe Journal of clinical endocrinology and metabolism2021
Association of Cognitive Function and Retinal Neural and Vascular Structure in Type 1 Diabetes.
Observational study in The Journal of clinical endocrinology and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Associations between retinal microvasculature and cognition in middle-aged adults with type 1 diabetes without overt neurological symptoms.Cerebral circulation - cognition and behavior · 2026Article
- Characterization of cognitive decline in long-duration type 1 diabetes by cognitive, neuroimaging, and pathological examinations.JCI insight · 2025Article
- The impact of type 1 diabetes mellitus on intellectual status: A Mendelian randomization study.Journal of education and health promotion · 2025Article
- Reduced Aqueous Retinol-Binding Protein 3 Concentration Is Associated With Diabetic Macular Edema and Progression of Diabetic Retinopathy.Diabetes care · 2025Article
- Decreased retinal vascular density is associated with cognitive impairment in CADASIL: an optical coherence tomography angiography study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Cognitive Performance and Diabetic Retinopathy: What Your Eyes Can Reveal About Your Brain.Current diabetes reviews · 2023Article
- Elevated Retinol Binding Protein 3 Concentrations Are Associated With Decreased Vitreous Inflammatory Cytokines, VEGF, and Progression of Diabetic Retinopathy.Diabetes care · 2022Article
- Risk factors for cognitive decline in type 2 diabetes mellitus patients in Brazil: a prospective observational study.Diabetology & metabolic syndrome · 2022Article
- Retinal Thickness Associates with Cognition Dysfunction in Young Adult with Type 1 Diabetes in Taiwan.Journal of diabetes research · 2022Article
- Diabetes mellitus associated neurovascular lesions in the retina and brain: A review.Frontiers in ophthalmology · 2022Review
- Toward a New Staging System for Diabetic Retinopathy Using Wide Field Swept-Source Optical Coherence Tomography Angiography.Current diabetes reports · 2021Review
- Performance Assessment of Two Different Approaches of Measuring Skeletonized Radial Peripapillary Capillary Vessel Density in Glaucoma Patients.Frontiers in medicine · 2021Article
- Retinal Imaging Techniques Based on Machine Learning Models in Recognition and Prediction of Mild Cognitive Impairment.Neuropsychiatric disease and treatment · 2021Article
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13 authors at 2 institutions in 1 country.
Funding
Abstract
contextCognitive dysfunction is a growing and understudied public health issue in the aging type 1 diabetic population and is difficult and time-consuming to diagnose. Studies in long duration type 1 diabetes have reported the presence of proliferative diabetic retinopathy was associated with cognitive dysfunction.
objectiveThis study assessed whether structural and vascular abnormalities of the retina, representing an extension of the central nervous system, are associated with cognitive impairment and other complications of type 1 diabetes.
methodsAn observational cross-sectional study of individuals with 50 or more years of type 1 diabetes (Joslin Medalist Study) was conducted at a university hospital in the United States. The study included 129 participants with complete cognitive testing. Validated cognitive testing measures included psychomotor speed, and immediate, and delayed memory. Optical coherence tomography (OCT) and OCT angiography (OCTA) were performed to obtain neural retinal layer thicknesses and vascular density for superficial (SCP) and deep retinal capillary plexus (DCP). Multivariable modeling was adjusted for potential confounders associated with outcomes in unadjusted analyses.
resultsDecreased vessel density of the SCP and DCP was associated with worse delayed memory (DCP: P = .002) and dominant hand psychomotor speed (SCP: P = .01). Thinning of the retinal outer nuclear layer was associated with worse psychomotor speed both in nondominant and dominant hands (P = .01 and P = .05, respectively). Outer plexiform layer thickness was associated with delayed memory (P = .04).
conclusionThese findings suggest that noninvasive retinal imaging using OCT and OCTA may assist in estimating the risks for cognitive dysfunction in people with type 1 diabetes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.