Trial reportThe Angle orthodontist2020
Effect of platelet-rich plasma on the rate of orthodontic tooth movement.
Trial report in The Angle orthodontist, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05766618 (The Effect of Multiple Injections of Platelets Rich Fibrin), which is not on this map. Cited by 33 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Multiple Injections of Platelets Rich Fibrin (i-PRF) on The Rate of Canine Retraction A Split-mouth: A Randomized Controlled Trial
Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The adjunctive effect of autologous platelet concentrates on orthodontic tooth movement: A systematic review and meta-analysis of current randomized controlled trials.International orthodontics · 2022Pooled it
- The effectiveness of locally injected platelet-rich plasma on orthodontic tooth movement acceleration.The Angle orthodontist · 2021Pooled it
- The effect of the local administration of biological substances on the rate of orthodontic tooth movement: a systematic review of human studies.Progress in orthodontics · 2021Pooled it
- Effect of archwire size on the rate of canine retraction in adult women : A randomized clinical trial.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2026Trial
- Effect of gradually increasing force magnitude on the rate of canine retraction: a split mouth randomized controlled trial.BMC oral health · 2026Trial
- A three-arm parallel split-mouth randomized controlled trial comparing injectable platelet-rich fibrin and low-level laser therapy on the rate of orthodontic tooth movement and canine angulation during en-masse retraction.The Angle orthodontist · 2026Trial
- Effectiveness of low frequency vibration on the rate of canine retraction: a randomized controlled clinical trial.Scientific reports · 2024Trial
- Trial
- Does leukocyte-platelet-rich fibrin (L-PRF) cause long term acceleration in the rate of canine retraction? A split-mouth, two-arm parallel group, randomized control trial.Dental press journal of orthodontics · 2023Trial
- Effect of injectable platelet-rich fibrin (i-PRF) in accelerating orthodontic tooth movement : A randomized split-mouth-controlled trial.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2021Trial
- Three-dimensional evaluation of the effects of injectable platelet rich fibrin (i-PRF) on alveolar bone and root length during orthodontic treatment: a randomized split mouth trial.BMC oral health · 2021Trial
- Review
- Evaluation of the effect of platelet-rich plasma on the rate of orthodontic tooth movement : A split-mouth controlled study.Journal of orthodontic science · 2026Article
- Evaluating the efficacy of platelet-rich fibrin in accelerating canine retraction following upper first premolar extraction: a split-mouth randomized controlled trial.Annals of medicine and surgery (2012) · 2025Article
- Evaluation of Efficacy of Advanced Platelet-rich Fibrin in Premolar Extraction Sockets as an Aid to Accelerate Orthodontic Tooth Movement and Wound Healing: A Split-mouthInternational journal of clinical pediatric dentistry · 2025Article
- Acceleration of Orthodontic Tooth Movement: A Bibliometric and Visual Analysis.International dental journal · 2025Article
- Comparison of two micro-osteoperforation protocols using mini-screws on the rate and type of extraction space closure: A randomized clinical trial.Dental research journal · 2025Article
- A Cross-Sectional Study: Dentists' Knowledge, Attitudes, and Perceptions of the Role of Plasma-Rich Protein and its Applications in Tooth Movement Rate.Journal of pharmacy & bioallied sciences · 2024Article
- Effectiveness of autologous leukocyte-platelet-rich fibrin on the rate of maxillary canine retraction, rotation, pain, and soft tissue healing: A split-mouth randomized controlled trial.Korean journal of orthodontics · 2024Article
- Systematic Review of Platelet-Rich Plasma in Medical and Surgical Specialties: Quality, Evaluation, Evidence, and Enforcement.Journal of clinical medicine · 2024Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the effect of local injection of platelet-rich plasma (PRP) on the rate of orthodontic tooth movement. MATERIALS AND
methodsSixteen female patients were randomly allocated in a split-mouth study design to receive PRP injections with CaCl2 activating solution on one side (intervention side) while the other side received CaCl2 injection only (control side). Canine retraction was performed on 0.017 × 0.025-inch stainless steel archwire applying 1.5 N retraction force. PRP and CaCl2 injections were done at 0, 3, and 6 weeks. The duration of the study was 4 months. Data were collected from digitized models. Assessment of pain accompanying the procedure was done using a visual analogue scale.
resultsThe rate of canine retraction was faster on the intervention side in the first 2 months, with a statistically significant difference in the first month (P = .049). On the other hand, the rate was statistically significantly slower on the intervention side in the third month following cessation of PRP injections (P = .02). Pain increased following injections on both sides.
conclusionsPRP showed a positive potential to accelerate the rate of tooth movement when injected in the first 2 months. Repeated injections of PRP to maintain a steady rate of accelerated tooth movement warrant further investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.