ArticlePloS one2020
Atypical alert state control in adult patients with ADHD: A pupillometry study.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- A comprehensive overview of the biological foundations of ADHD.Bioscience reports · 2026Review
- The Pupil-Brain System at Rest: Spontaneous Pupil Fluctuations as Markers of Neuromodulatory and Network Dynamics.Psychophysiology · 2026Review
- Investigating the test-retest reliability and behavioral correlates of pupil responses in the n-back task.Scientific reports · 2026Article
- Unraveling children's mental rotation: insights from behavior and eye tracking.Scientific reports · 2026Article
- Temporal variability in pupillary asymmetry reflects ADHD-related traits in preschool and early school-aged children.Frontiers in cognition · 2026Article
- Multimodal biomarker based on temporal complexity of eye movements and pupil diameter in attention-deficit/hyperactivity disorder.PLOS mental health · 2025Article
- Multiple factors contribute to pupillary light reflex: implications for screening of traumatic brain injury in military service members.Clinical neurophysiology practice · 2025Article
- Stimulation of Locus Ceruleus Inputs to the Prelimbic Cortex in Mice Induces Cell Type-Specific Expression of theeNeuro · 2024Article
- Stimulation of locus coeruleus inputs to the frontal cortex in mice induces cell type-specific expression of thebioRxiv : the preprint server for biology · 2024Article
- Advances in the etiology and neuroimaging of children with attention deficit hyperactivity disorder.Frontiers in pediatrics · 2024Review
- Recent trends in multiple metrics and multimodal analysis for neural activity and pupillometry.Frontiers in neurology · 2024Article
- The Central Noradrenergic System in Neurodevelopmental Disorders: Merging Experimental and Clinical Evidence.International journal of molecular sciences · 2023Review
- Measures of tonic and phasic activity of the locus coeruleus-norepinephrine system in children with autism spectrum disorder: An event-related potential and pupillometry study.Autism research : official journal of the International Society for Autism Research · 2022Article
- Distractibility and impulsivity neural states are distinct from selective attention and modulate the implementation of spatial attention.Nature communications · 2022Article
- Pupil dilation predicts individual self-regulation success across domains.Scientific reports · 2021Article
- Identification of attention-deficit hyperactivity disorder based on the complexity and symmetricity of pupil diameter.Scientific reports · 2021Article
- Catching Mind Wandering With Pupillometry: Conceptual and Methodological Challenges.Wiley interdisciplinary reviews. Cognitive scienceReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although behavioral studies have repeatedly demonstrated that individuals with attention-deficit/hyperactivity disorder (ADHD) have deficits in alertness, little is known about its underlying neural basis. It is hypothesized that pupil diameter reflects the firing of norepinephrine (NE) neurons in the locus coeruleus (LC), and that the LC-NE neuromodulatory system for regulating alertness may be dysfunctional in ADHD. To clinically and non-invasively examine this hypothesis, we monitored the kinetics of pupil diameter in response to stimuli and compared them between adults with ADHD (n = 17) and typically developing (TD) adults (n = 23) during an auditory continuous performance task. Individuals in the ADHD group exhibited a significantly larger tonic pupil diameter, and a suppressed stimulus-evoked phasic pupil dilation, compared to those in the TD group. These findings provide support for the idea that the aberrant regulatory control of pupil diameter in adults with ADHD may be consistent with a compromised state of alertness resulting from a hyperactivated LC-NE system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.