ReviewAging2020
ARDD 2020: from aging mechanisms to interventions.
Abstract readReview
In one paragraph
Review in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Personalist Bioethics as a Guide to Assessing Emerging Anti-aging Therapies.The Linacre quarterly · 2026Article
- Comprehensive characterisation of age-related changes in cell subpopulations and tissue structural properties in secondary lymphoid organs.Cell death & disease · 2025Article
- Age reprogramming: Innovations and ethical considerations for prolonged longevity (Review).Biomedical reports · 2025Review
- Epigenetic Clock Analysis for National Institutes of Health Stroke Scale in Patients With Ischemic Stroke.Neuropsychopharmacology reports · 2025Article
- Biological aging analysis based on DNA methylation status for social anxiety disorder.Neuropsychopharmacology reports · 2024Article
- Meta-analyses of epigenetic age acceleration and GrimAge components of schizophrenia or first-episode psychosis.Schizophrenia (Heidelberg, Germany) · 2024Article
- Cellular Senescence: The Driving Force of Musculoskeletal Diseases.Biomedicines · 2024Review
- Human Aging and Age-Related Diseases: From Underlying Mechanisms to Pro-Longevity Interventions.Aging and disease · 2024Review
- Reduced Taurine Serum Levels in Inflammatory Bowel Disease.Nutrients · 2024Article
- Taurine as a possible therapy for immunosenescence and inflammaging.Cellular & molecular immunology · 2024Article
- Association between cardiometabolic index and biological aging in the US population: evidence from NHANES 2015-2020.Frontiers in aging neuroscience · 2024Article
- Taurine deficiency as a driver of aging.Science (New York, N.Y.) · 2023Article
- Phenomic Studies on Diseases: Potential and Challenges.Phenomics (Cham, Switzerland) · 2023Review
- Review
- MYTHO is a novel regulator of skeletal muscle autophagy and integrity.Nature communications · 2023Article
- Clinical Epigenomic Explanation of the Epidemiology of Cannabinoid Genotoxicity Manifesting as Transgenerational Teratogenesis, Cancerogenesis and Aging Acceleration.International journal of environmental research and public health · 2023Review
- Dietary cobalt oxide nanoparticles alleviate aging through activation of mitochondrial UPR inTheranostics · 2023Article
- Perturbation of 3D nuclear architecture, epigenomic dysregulation and aging, and cannabinoid synaptopathy reconfigures conceptualization of cannabinoid pathophysiology: part 1-aging and epigenomics.Frontiers in psychiatry · 2023Review
- Deep generative molecular design reshapes drug discovery.Cell reports. Medicine · 2022Review
- Ageing and cancer: a research gap to fill.Molecular oncology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
66 authors.
Garik V MkrtchyanCenter for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Kotb AbdelmohsenLaboratory of Genetics and Genomics, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.
Pénélope AndreuxAmazentis SA, EPFL Innovation Park, Bâtiment C, Lausanne, Switzerland.
Ieva BagdonaiteCenter for Glycomics, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Nir BarzilaiDepartment of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Søren BrunakNovo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.
Filipe CabreiroInstitute of Clinical Sciences, Imperial College London, Hammersmith Hospital Campus, London, W12 0NN, UK.
Rafael de CaboExperimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Judith CampisiBuck Institute for Research on Aging, Novato, CA 94945, USA.
Ana Maria CuervoDepartment of Developmental and Molecular Biology, Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Marco DemariaEuropean Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, The Netherlands.
Collin Y EwaldInstitute of Translational Medicine, Department of Health Sciences and Technology, Swiss Federal Institute for Technology Zürich, Switzerland.
Evandro Fei FangDepartment of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, 1478 Lørenskog, Norway.
Richard FaragherSchool of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, UK.
Luigi FerrucciLongitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Adam FreundCalico Life Sciences, LLC, South San Francisco, CA 94080, USA.
Carlos G Silva-GarcíaDepartment of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
Anastasia GeorgievskayaHautAI OÜ, Tallinn, Estonia.
Vadim N GladyshevDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
David J GlassRegeneron Pharmaceuticals, Inc. Tarrytown, NY 10591, USA.
Vera GorbunovaDepartments of Biology and Medicine, University of Rochester, Rochester, NY 14627, USA.
Aubrey de GreySENS Research Foundation, Mountain View, CA 94041, USA.
Wei-Wu HeHuman Longevity Inc., San Diego, CA 92121, USA.
Jan HoeijmakersDepartment of Genetics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Eva HoffmannDNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Steve HorvathHuman Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Riekelt H HoutkooperLaboratory Genetic Metabolic Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Majken K JensenSection of Epidemiology, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Martin Borch JensenGordian Biotechnology, San Francisco, CA 94107, USA.
Alice KaneBlavatnik Institute, Department of Genetics, Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, Boston, MA 94107, USA.
Moustapha KassemMolecular Endocrinology Unit, Department of Endocrinology, University Hospital of Odense and University of Southern Denmark, Odense, Denmark.
Peter de KeizerDepartment of Molecular Cancer Research, Center for Molecular Medicine, Division of Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Brian KennedyBuck Institute for Research on Aging, Novato, CA 94945, USA.
Gerard KarsentyDepartment of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA.
Dudley W LammingDepartment of Medicine, University of Wisconsin-Madison and William S. Middleton Memorial Veterans Hospital, Madison, WI 53792, USA.
Kai-Fu LeeSinovation Ventures and Sinovation AI Institute, Beijing, China.
Nanna MacAulayDepartment of Neuroscience, University of Copenhagen, Denmark.
Polina MamoshinaDeep Longevity Inc., Hong Kong Science and Technology Park, Hong Kong.
Jim MellonJuvenescence Limited, Douglas, Isle of Man, UK.
Marte MolenaarsLaboratory Genetic Metabolic Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Alexey MoskalevInstitute of Biology of FRC Komi Science Center of Ural Division of RAS, Syktyvkar, Russia.
Andreas MundNovo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.
Laura NiedernhoferInstitute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Brenna OsborneCenter for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Heidi H PakDepartment of Medicine, University of Wisconsin-Madison and William S. Middleton Memorial Veterans Hospital, Madison, WI 53792, USA.
Andrey ParkhitkoUniversity of Pittsburgh, Pittsburgh, PA 15260, USA.
Nuno RaimundoInstitute of Cellular Biochemistry, University Medical Center Goettingen, Goettingen, Germany.
Thomas A RandoDepartment of Neurology and Neurological Sciences and Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, CA 94305, USA.
Lene Juel RasmussenCenter for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Carolina ReisOneSkin Inc., San Francisco, CA 94107, USA.
Christian G RiedelDepartment of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden.
Anais Franco-RomeroDepartment of Biomedical Sciences, University of Padova, Italy.
Björn SchumacherInstitute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, Cologne, Germany.
David A SinclairBlavatnik Institute, Department of Genetics, Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School, Boston, MA 94107, USA.
Yousin SuhDepartments of Obstetrics and Gynecology, Genetics and Development, Columbia University, New York, NY 10027, USA.
Pam R TaubDivision of Cardiovascular Medicine, University of California, San Diego, CA 92093, USA.
Debra ToiberDepartment of Life Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Jonas T TreebakNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
Dario Riccardo ValenzanoMax Planck Institute for Biology of Ageing, Cologne, Germany.
Eric VerdinBuck Institute for Research on Aging, Novato, CA 94945, USA.
Jan VijgDepartment of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Sergey YoungLongevity Vision Fund, New York, NY 10022, USA.
Lei ZhangInstitute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Daniela BakulaCenter for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Alex ZhavoronkovInsilico Medicine, Hong Kong Science and Technology Park, Hong Kong.
Morten Scheibye-KnudsenCenter for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Funding
THE IMPACT OF CELLULAR DEFENSE ON THE ROLE OF Ku80 IN GENOME MAINTENANCE AND LONGP01AG017242 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI VIJG, JAN · 1999 to 2023
$46.1MThe role of hyaluronan in longevity and cancer resistance of longest-lived rodentP01AG047200 · NIA · UNIVERSITY OF ROCHESTER · PI Vadim N. Gladyshev · 2014 to 2026
$36.9MRole of Autophagy in T Cell Function and Immunosenescence (Project 3)P01AG031782 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CUERVO, ANA MARIA · 2009 to 2024
$36.2MSomatic Activation of Retrotransposition: A New Molecular Mechanism of Aging?P01AG051449 · NIA · BROWN UNIVERSITY · PI John M Sedivy · 2016 to 2026
$30.4MWnt signaling in muscle stem cell agingP01AG036695 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARGARET A. GOODELL · 2011 to 2026
$29.3MValidation and characterization of the identified variants associated with human longevity in mouse modelsU19AG056278 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JAN VIJG · 2017 to 2026
$24.5MThe role of SIRT6 posttranslational modifications in aging and genome stability. Supplement: Testing SIRT6 activators as potential Alzheimer's disease therapy.R01AG027237 · NIA · UNIVERSITY OF ROCHESTER · PI Vera Gorbunova · 2006 to 2026
$6.2MRole of Sgs1 DNA helicase in telomere maintenanceR01AG019719 · NIA · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI SINCLAIR, DAVID A. · 2001 to 2022
$5.3MDecreased Protein Degradation in AgingR37AG021904 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI CUERVO, ANA MARIA · 2013 to 2022
$4.4MSIRT1 as a regulator of health and lifespan of mammalsR37AG028730 · NIA · HARVARD MEDICAL SCHOOL · PI SINCLAIR, DAVID A. · 2012 to 2021
$4.1MUsing the senolytic fisetin to suppress mortality in aged mice acutely exposed to murine beta-coronavirusR01AG063543 · NIA · UNIVERSITY OF MINNESOTA · PI NIEDERNHOFER, LAURA JANE · 2019 to 2023
$3.4MThe regulation of health and longevity by branched-chain amino acidsR01AG056771 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Dudley William Lamming · 2018 to 2026
$3.1MBLRD VA I01 BX004031Medical Research Council MC_UP_1605/6NHLBI NIH HHS U01 HL145560NIA NIH HHS F31 AG066311NIA NIH HHS K99 AG041765NIA NIH HHS K99 AG057792NIA NIH HHS K99 AG065508NIA NIH HHS P01 AG017242NIA NIH HHS P01 AG031782NIA NIH HHS P01 AG036695NIA NIH HHS P01 AG047200NIA NIH HHS P01 AG051449NIA NIH HHS R00 AG041765NIA NIH HHS R00 AG057792NIA NIH HHS R01 AG019719NIA NIH HHS R01 AG027237NIA NIH HHS R01 AG056771NIA NIH HHS R01 AG062328NIA NIH HHS R01 AG063543NIA NIH HHS R21 AG050135NIA NIH HHS R21 AG051974NIA NIH HHS R37 AG021904NIA NIH HHS R37 AG028730NIA NIH HHS R56 AG056771NIA NIH HHS RF1 AG054108NIA NIH HHS RF1 AG056771NIA NIH HHS U19 AG056278Wellcome Trust
Abstract
Aging is emerging as a druggable target with growing interest from academia, industry and investors. New technologies such as artificial intelligence and advanced screening techniques, as well as a strong influence from the industry sector may lead to novel discoveries to treat age-related diseases. The present review summarizes presentations from the 7
Indexed as
AgingArtificial IntelligenceBiomedical ResearchLongevityCellular SenescenceCongresses as TopicDrug DiscoveryHumansLife StylePharmaceutical PreparationsPharmaceutical Preparationsagingartificial intelligencedrug discoveryinterventions
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.