Evidence map›Paper›PMID 33378226›Full record

ArticleMolecular biology of the cell2021

The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.

Shalini Menon, Dennis Goldfarb, Chris T Ho, Erica W Cloer, Nicholas P Boyer, Christopher Hardie, Andrew J Bock, Emma C Johnson, Joel Anil, M Ben Major and 1 more

Open access · greenAbstract read
In one paragraph

Article in Molecular biology of the cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
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  17. Journal of Cancer · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Shalini MenonDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Dennis GoldfarbLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Chris T HoDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Erica W CloerDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Nicholas P BoyerNeuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Christopher HardieDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Andrew J BockDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Emma C JohnsonDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Joel AnilDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
M Ben MajorDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
Stephanie L GuptonDepartment of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.
University of North Carolina at Chapel Hill · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5M
Undergraduate Research: Coordinated Cytoskeletal Dynamics and Membrane Remodeling in Cellular Shape ChangeR35GM135160 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Gupton · 2020 to 2026
$3.3M
Identification of ubiquitnated substrates of TRIM9 and TRIM67R21MH109653 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GUPTON, STEPHANIE · 2016 to 2017
$417k
NCI NIH HHS P30 CA016086NIGMS NIH HHS R35 GM135160NIMH NIH HHS R21 MH109653
6 · The paper itself

Abstract

TRIM9 and TRIM67 are neuronally enriched E3 ubiquitin ligases essential for appropriate morphogenesis of cortical and hippocampal neurons and fidelitous responses to the axon guidance cue netrin-1. Deletion of murine

Indexed as

Adaptor Proteins, Signal TransducingAnimalsAxonsCytoskeletal ProteinsFemaleGrowth ConesHippocampusMaleMiceMice, Inbred C57BLMice, KnockoutMorphogenesisNerve Tissue ProteinsNeuronsProtein Interaction MappingProtein Interaction MapsAdaptor Proteins, Signal TransducingCytoskeletal ProteinsNerve Tissue ProteinsTRIM67 protein, mouseTrim9 protein, mouseTripartite Motif ProteinsUbiquitin-Protein Ligases

Identifiers

PMID33378226
PMCPMC8098814
OpenAlexW3114171701

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.