Evidence map›Paper›PMID 33378215›Full record

ArticleMolecular biology of the cell2021

Epistatic, synthetic, and balancing interactions among tubulin missense mutations affecting neurite growth in

Ho Ming Terence Lee, Natalie Yvonne Sayegh, A Sophia Gayek, Susan Laura Javier Jao, Martin Chalfie, Chaogu Zheng

Open access · bronzeAbstract read
In one paragraph

Article in Molecular biology of the cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. TUBB3 and KIF21A in neurodevelopment and disease.Frontiers in neuroscience · 2023
    Review
  10. Article
  11. The Expression and Function of Tubulin Isotypes inFrontiers in cell and developmental biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Ho Ming Terence LeeSchool of Biological Sciences, The University of Hong Kong, Hong Kong SAR, China.
Natalie Yvonne SayeghDepartment of Biological Sciences, Columbia University, New York, NY 10027.
A Sophia GayekDepartment of Biological Sciences, Columbia University, New York, NY 10027.
Susan Laura Javier JaoDepartment of Biological Sciences, Columbia University, New York, NY 10027.
Martin ChalfieDepartment of Biological Sciences, Columbia University, New York, NY 10027.
Chaogu ZhengSchool of Biological Sciences, The University of Hong Kong, Hong Kong SAR, China.
Columbia University · USUniversity of Hong Kong · HK

Funding

GENETIC ANALYSIS OF NEMATODE CELL DIFFERENTIATIONR01GM030997 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI CHALFIE, MARTIN · 1985 to 2017
$7.1M
GENETIC ANALYSIS OF NEMATODE CELL DIFFERENTIATIONR37GM030997 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI CHALFIE, MARTIN · 1999 to 2009
$6.6M
Genetic analysis of nematode cell differentiationR35GM122522 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI MARTIN CHALFIE · 2017 to 2026
$6.5M
NIGMS NIH HHS R01 GM030997NIGMS NIH HHS R35 GM122522NIGMS NIH HHS R37 GM030997
6 · The paper itself

Abstract

Mutations in tubulins affect microtubule (MT) dynamics and functions during neuronal differentiation and their genetic interaction provides insights into the regulation of MT functions. We previously used

Indexed as

AllelesAmino Acid SequenceAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsMicrotubulesMutationMutation, MissenseNeuritesNeurogenesisPhenotypeTubulinCaenorhabditis elegans ProteinsTubulin

Identifiers

PMID33378215
PMCPMC8098816
OpenAlexW3115856896

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.