ArticleActa ophthalmologica2021
Design and Pilot data of the high myopia registration study: Shanghai Child and Adolescent Large-scale Eye Study (SCALE-HM).
Article in Acta ophthalmologica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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12 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Axial length as a predictor of myopic macular degeneration: a meta-analysis and clinical study.Eye (London, England) · 2025Pooled it
- Adult myopia progression in high myopes aged 18-25 years: evidence from a population-based cohort.The British journal of ophthalmology · 2026Article
- The influence of intraocular pressure in the onset and progression of myopia in children and adolescents: a review of mechanisms and clinical significance.Frontiers in medicine · 2026Review
- Comprehensive bioinformatics analysis of metabolism‑related microRNAs in high myopia in young and old adults with age‑related cataracts.Molecular medicine reports · 2025Article
- Article
- A deep learning system for myopia onset prediction and intervention effectiveness evaluation in children.NPJ digital medicine · 2024Article
- Myopic maculopathy among Chinese children with high myopia and its association with choroidal and retinal changes: the SCALE-HM study.The British journal of ophthalmology · 2024Article
- Peripheral and posterior pole retinal changes in highly myopic Chinese children and adolescents : Retinal changes in Chinese children and adolescents.BMC ophthalmology · 2024Article
- Spontaneously Myopic Guinea Pig: Model of Early Pathologic Myopia.Investigative ophthalmology & visual science · 2023Article
- Short-term clinic observation of misalignment and rotational stability after implantable collamer lens implantation.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Article
- Prevalence and Characteristics of Myopia in Adult Non-Human Primates in Southwest China.Translational vision science & technology · 2023Article
- Does PLEXJournal of clinical medicine · 2023Article
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo describe the methodology and pilot data of the Shanghai Child and Adolescent Large-scale Eye Study (SCALE-HM).
methodsThis is a population-based, prospective, examiner-masked study with annual follow-up. Patients are 4- to 18-year-olds with high myopia. The participants will fill out questionnaires and then undergo visual acuity, axial length (AL), intraocular pressure, ophthalmologist assessment, microperimetry, cycloplegic refraction, Pentacam, wavefront aberration, fundus, blood and saliva examinations. To describe the pilot data, intergroup differences were assessed with t-tests or analysis of variance and a logistic regression model was used to determine the independent factors associated with peripapillary atrophy (PPA).
resultsOverall, 134 eyes of 79 participants met the pilot study recruitment criteria. The mean AL and spherical equivalent were 26.91 ± 1.07 mm and -9.40 ± 1.77 D, respectively. Peripapillary atrophy (PPA) (N = 112) and tessellated fundus (N = 67) were the most common fundus changes. The mean AL was significantly longer in PPA (27.08 ± 0.93 mm) than in non-PPA eyes (26.06 ± 1.31 mm; p < 0.001). Axial length (AL) (p = 0.041) was the only independent factor associated with PPA. Axial length (AL) was significantly longer in eyes with diffuse chorioretinal atrophy (N = 11; 28.02 ± 1.31 mm) than without myopic retinal lesions (N = 56; 26.48 ± 0.91 mm, p < 0.001) or with tessellated fundus (N = 67; 27.09 ± 0.97 mm, p = 0.012). The myopic degree was higher in eyes with diffuse chorioretinal atrophy than without myopic retinal lesions (-10.51 ± 2.76 D versus -9.06 ± 1.58 D, p = 0.039).
conclusionPeripapillary atrophy and tessellated fundus were common in children and adolescents with high myopia. Results from this prospective study will help to understand the mechanisms, development and prognosis of these changes and can guide early myopia screening.
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