Evidence map›Paper›PMID 33377540›Full record

ArticleInternational journal of geriatric psychiatry2021

Neuroticism, negative life events, and dementia in older White and Black Brazilians.

Ana W Capuano, Robert S Wilson, Sue E Leurgans, Carolina Sampaio, Lisa L Barnes, Jose M Farfel, David A Bennett

Abstract read
In one paragraph

Article in International journal of geriatric psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Quantifying longitudinal cognitive resilience to Alzheimer's disease and other neuropathologies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022
    Article
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ana W CapuanoRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.ORCID 0000-0002-3505-344X
Robert S WilsonRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.ORCID 0000-0001-9592-0333
Sue E LeurgansRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Carolina SampaioInstituto de Assistência Médica Ao Servidor Público Estadual (IAMSPE), São Paulo, Brazil.
Lisa L BarnesRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Jose M FarfelRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.

Funding

African Ancestry and the Genomic Architecture of AD and Other Common Neurodegenerative Disease NeuropathologiesR01AG054058 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2016 to 2023
$8.9M
NIA NIH HHS R01 AG054058NIA NIH HHS R01AG54058
6 · The paper itself

Abstract

objectiveExposure to negative life events (NLEs) and neuroticism are associated with dementia. It is unknown whether neuroticism explains or modifies the association of NLEs with dementia in older Black and White Brazilians.

methodsA total of 1747 decedents 65 years and older White and Black (11% Black and 23% Mixed) Brazilians, 53% women, were included in the analyses. Data were obtained in a face-to-face interview with an informant (71% their children) who knew the decedents for 47 years on average. Dementia was classified using the Clinical Dementia Rating. NLEs were assessed with a 10-item scale involving common problems (e.g., death, illness, alcoholism, and financial). Neuroticism was assessed with a 6-item neuroticism scale adapted from the NEO Five-Factor Inventory. Models adjusted for age, sex, and education. Black and mixed-race were combined in the analyses.

resultsNLEs (median of 2) were more common in Blacks than Whites (2.04 vs. 1.82, p = 0.007). More NLEs increased the odds of dementia (OR = 1.112, β = 0.106, p = 0.002), similarly in Blacks and Whites (β

conclusionThe association of NLEs and dementia is partially explained by neuroticism in older White but not in Blacks Brazilians.

Indexed as

Black or African AmericanDementiaAgedBrazilFemaleHumansMaleNeuroticismWhite PeopleAfrican AmericanBlackBrazilBraziliansdementiaLatinoslife eventsneuroticismpsychosocial stressorsWhite

Identifiers

PMID33377540
PMCPMC8384138

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.