Evidence map›Paper›PMID 33377315›Full record

ArticleMolecular oral microbiology2021

PG1659 functions as anti-sigma factor to extracytoplasmic function sigma factor RpoE in Porphyromonas gingivalis W83.

Yuetan Dou, Hiel Rutanhira, Norbert Schormann, Champion Deivanayagam, Hansel M Fletcher

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular oral microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Multiple factors regulate the expression ofFrontiers in cellular and infection microbiology · 2024
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yuetan DouDepartment of Microbiology and Molecular Genetics, School of Medicine, Loma Linda University, Loma Linda, CA, USA.
Hiel RutanhiraDepartment of Microbiology and Molecular Genetics, School of Medicine, Loma Linda University, Loma Linda, CA, USA.
Norbert SchormannDepartment of Biochemistry and Molecular Genetics, School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA.
Champion DeivanayagamDepartment of Biochemistry and Molecular Genetics, School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA.
Hansel M FletcherDepartment of Microbiology and Molecular Genetics, School of Medicine, Loma Linda University, Loma Linda, CA, USA.ORCID 0000-0002-7165-2159
Loma Linda University · USUniversity of Alabama at Birmingham · US

Funding

Studies on virulence regulation in PorphyromonasR01DE013664 · NIDCR · LOMA LINDA UNIVERSITY · PI FLETCHER, HANSEL M. · 2002 to 2011
$3.3M
Mechanisms for adaptation to oxidative stress in Porphyromonas gingivalisR01DE019730 · NIDCR · LOMA LINDA UNIVERSITY · PI FLETCHER, HANSEL M. · 2009 to 2013
$2.0M
Studies on the virulence regulation in PorphyromonasR01DE025852 · NIDCR · LOMA LINDA UNIVERSITY · PI FLETCHER, HANSEL M. · 2016 to 2020
$2.0M
ECF sigma factors in adaptation and virulence of Porphyromonas gingivalisR01DE022508 · NIDCR · LOMA LINDA UNIVERSITY · PI FLETCHER, HANSEL M. · 2012 to 2016
$1.8M
Studies on the virulence of Fillifactor alocisR21DE022724 · NIDCR · LOMA LINDA UNIVERSITY · PI FLETCHER, HANSEL M. · 2012 to 2013
$427k
Studies on the virulence regulation in PorphyromonasR56DE013664 · NIDCR · LOMA LINDA UNIVERSITY · PI FLETCHER, HANSEL M. · 2014 to 2014
$291k
NIDCR NIH HHS R01 DE013664NIDCR NIH HHS R01 DE019730NIDCR NIH HHS R01 DE022508NIDCR NIH HHS R01 DE025852NIDCR NIH HHS R21 DE022724NIDCR NIH HHS R56 DE013664
6 · The paper itself

Abstract

Anti-sigma factors play a critical role in regulating the expression of sigma factors in response to environmental stress signals. PG1659 is cotranscribed with an upstream gene PG1660 (rpoE), which encodes for a sigma factor that plays an important role in oxidative stress resistance and the virulence regulatory network of P. gingivalis. PG1659, which is annotated as a hypothetical gene, is evaluated in this study. PG1659, composed of 130 amino acids, is predicted to be transmembrane protein with a single calcium (Ca

Indexed as

Porphyromonas gingivalisSigma FactorBacterial ProteinsGene Expression Regulation, BacterialStress, PhysiologicalVirulenceBacterial ProteinsSigma Factoranti-sigma factoroxidative stressPorphyromonas gingivalissigma factor

Identifiers

PMID33377315
PMCPMC7940587
OpenAlexW3115753328

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.