Trial reportThe Gerontologist2022
Findings of Sequential Pilot Trials of Aliviado Dementia Care to Inform an Embedded Pragmatic Clinical Trial.
Trial report in The Gerontologist, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03681119 (The Hospice Advanced Dementia Symptom Management and Quality of Life Trial), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Hospice Advanced Dementia Symptom Management and Quality of Life Trial (HAS-QOL)
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Hospice interventions for persons living with dementia, family members and clinicians: A systematic review.Journal of the American Geriatrics Society · 2022Pooled it
- Trial
- An App for Care Partners of Persons Living With Dementia (Aliviado Caregiving): Human-Centered Design Study.JMIR formative research · 2026Article
- Nurse-Led Telephonic Care Following Emergency Department Visits for Persons Living With Dementia and Their Care Partners: A Program Description.Journal of the American Geriatrics Society · 2026Article
- Challenges and solutions of conducting dementia clinical trials: A palliative care at home pilot for persons with dementia.Journal of the American Geriatrics Society · 2024Article
- Models of care for people with dementia approaching end of life: A rapid review.Palliative medicine · 2023Review
- Functional and clinical needs of older hospice enrollees with coexisting dementia.Journal of the American Geriatrics Society · 2023Article
- Implementing Palliative Care Teams Specialized in Dementia in Two Countries: Experiences of Failure and Success.Journal of Alzheimer's disease : JAD · 2023Article
- Ethical challenges of prospective clinical trials during the COVID-19 pandemic.Expert review of anti-infective therapy · 2022Article
- A Pilot Observational Exploratory Study of Well-Being in Hospice Interdisciplinary Team Members.The American journal of hospice & palliative care · 2022Observational
- Article
- "I Didn't Sign Up for This": Perspectives from Persons Living with Dementia and Care Partners on Challenges, Supports, and Opportunities to Add Geriatric Neuropalliative Care to Dementia Specialty Care.Journal of Alzheimer's disease : JAD · 2022Article
- Aliviado Mobile App for Hospice Providers: A Usability Study.Journal of pain and symptom management · 2022Article
- Comprehensive Dementia Care Models: State of the Science and Future Directions.Research in gerontological nursingReview
- Supporting dementia family care partners during COVID-19: Perspectives from hospice staff.Geriatric nursing (New York, N.Y.)Article
Corrections and comments
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Authors and funding
14 authors at 8 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
objectivesMany investigators of Alzheimer's disease and related dementias (AD/ADRD) are unfamiliar with the embedded pragmatic clinical trials (ePCTs) and the indispensable pilot phase preceding ePCTs. This paper provides a much-needed example for such a pilot phase and discusses implementation barriers and additional infrastructure and implementation strategies developed in preparation for a nationwide AD/ADRD ePCT. RESEARCH DESIGN AND
methodsTwo pilot trials were conducted in 2 hospices sequentially to refine and test Aliviado Dementia Care-Hospice Edition, a complex quality improvement intervention for advanced dementia symptom management. Readiness for the subsequent full-scale ePCT was assessed by three milestones: ≥80% training completion rate ("feasibility"), ≥80% posttraining survey respondents indicating intention for practice changes ("applicability"), and at least 1 Aliviado care plan/assessment instrument administered in ≥75% of dementia patients admitted to home hospice within 1-month posttraining ("fidelity").
resultsParticipants included 72 interdisciplinary team members and 11 patients with AD/ADRD across the pilots. Feasibility, applicability, and fidelity outcomes (92%, 93%, and 100%, respectively) all surpassed the preestablished milestones (80%, 80%, and 75%). Main implementation challenges were related to hospice staff turnover, integration of the Aliviado toolbox materials within the electronic health records, and hospices' limited research experience and infrastructure. DISCUSSION AND IMPLICATIONS: This pilot phase demonstrated feasibility, applicability, and fidelity required to proceed to the full-scale ePCT. Our study findings and discussions of additional infrastructure and implementation strategies developed following the pilot phase can inform researchers and clinicians interested in conducting AD/ADRD-related pilot studies for ePTCs or quality improvement initiatives. CLINICAL TRIALS REGISTRATION NUMBER: NCT03681119.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.