ArticleCell reports. Medicine2020
Dissociable Motivational Deficits in Pre-manifest Huntington's Disease.
Article in Cell reports. Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Apathy, effort-based decisions and brain integrity in Alzheimer's and Parkinson's diseases.Brain : a journal of neurology · 2026Article
- Shared and distinct features of common effort-based decision-making paradigms and their relation to brain structure and neuropsychiatric conditions: An integrated narrative review.Cognitive, affective & behavioral neuroscience · 2026Review
- Decision context and neurobehavioural disturbance in Huntington's disease.Cognitive, affective & behavioral neuroscience · 2026Article
- Decision cost hypersensitivity underlies Huntington's disease apathy.Brain : a journal of neurology · 2025Article
- The effect of Huntington's disease on cognitive and physical motivation.Brain : a journal of neurology · 2024Article
- Dissociable neural after-effects of cognitive and physical effort expenditure during reward evaluation.Cognitive, affective & behavioral neuroscience · 2023Article
- Amphetamines Improve the Motivation to Invest Effort in Attention-Deficit/Hyperactivity Disorder.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Associations Between Cognitive and Physical Effort-Based Decision Making in People With Schizophrenia and Healthy Control Subjects.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Disordered Decision Making: A Cognitive Framework for Apathy and Impulsivity in Huntington's Disease.Movement disorders : official journal of the Movement Disorder Society · 2022Review
- Sleep Restriction Reduces Cognitive but Not Physical Motivation.Nature and science of sleep · 2022Article
- Neurocomputational mechanisms underlying the subjective value of information.Communications biology · 2021Article
- Heightened effort discounting is a common feature of both apathy and fatigue.Scientific reports · 2021Article
- Choosing increases the value of non-instrumental information.Scientific reports · 2021Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Motivation is characterized by a willingness to overcome both cognitive and physical effort costs. Impairments in motivation are common in striatal disorders, such as Huntington's disease (HD), but whether these impairments are isolated to particular domains of behavior is controversial. We ask whether HD differentially affects the willingness of individuals to overcome cognitive versus physical effort. We tested 20 individuals with pre-manifest HD and compared their behavior to 20 controls. Across separate trials, participants made choices about how much cognitive or physical effort they were willing to invest for reward. Our key results were that individuals with pre-manifest HD were less willing than controls to invest cognitive effort but were no different in their overall preference for physical effort. These results cannot be explained by group differences in neuropsychological or psychiatric profiles. This dissociation of cognitive- and physical-effort-based decisions provides important evidence for separable, domain-specific mechanisms of motivation.
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