Evidence map›Paper›PMID 33377082›Full record

ArticleSTAR protocols2020

Intratumoral Monocyte Transfer to Examine Monocyte Differentiation in the Tumor Microenvironment.

Samir Devalaraja, Malay Haldar

Open access · goldAbstract read
In one paragraph

Article in STAR protocols, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Samir DevalarajaDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Malay HaldarDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Cancer Research Institute · USUniversity of Pennsylvania · US

Funding

Regulation of antigen presenting cells in the tumor microenvironment by retinoic acidR37CA234027 · NCI · UNIVERSITY OF PENNSYLVANIA · PI HALDAR, MALAY · 2019 to 2025
$2.6M
Role of Retinoic Acid on Mononuclear Phagocytes in the Sarcoma MicroenvironmentF30CA236464 · NCI · UNIVERSITY OF PENNSYLVANIA · PI DEVALARAJA, SAMIRKUMAR S · 2019 to 2020
$48k
NCI NIH HHS F30 CA236464NCI NIH HHS R37 CA234027
6 · The paper itself

Abstract

The regulation of monocyte differentiation in the tumor microenvironment is of significant interest to tumor immunologists. Monocytes injected into the circulation may not track into tumors in sufficient numbers, making intratumoral injections a preferred experimental approach. Monocyte enrichment with antibody-based positive selection may activate downstream signaling, while cell sorters expose monocytes to mechanical stress. Here, we describe an approach of intratumoral monocyte transfer that circumvents these limitations by using negative selection and fluorescent reporter mice. For complete details on the use and execution of this protocol, please refer to Devalaraja et al. (2020).

Indexed as

Cell DifferentiationTumor MicroenvironmentAnimalsFemaleMaleMice, Inbred C57BLMicrospheresMonocytesNeoplasmsCancerCell isolationFlow Cytometry/Mass CytometryImmunology

Identifiers

PMID33377082
PMCPMC7757421
OpenAlexW3109519669

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.