Evidence map›Paper›PMID 33377027›Full record

ArticleSTAR protocols2020

A Protocol for Studying HIV-1 Envelope Glycoprotein Function.

Sneha Ratnapriya, Angela Chov, Alon Herschhorn

Open access · goldAbstract read
In one paragraph

Article in STAR protocols, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 26 citations in OpenAlex.

  1. Highly efficient production of HIV-1Journal of virology · 2025
    Article
  2. Article
  3. Article
  4. In vivo evolution of env in SHIV-AD8Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  5. Incompletely closed HIV-1Npj viruses · 2025
    Article
  6. mRNA-based HIV-1 vaccines.Clinical microbiology reviews · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Alternative substitutions of N332 in HIV-1bioRxiv : the preprint server for biology · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sneha RatnapriyaDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
Angela ChovDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
Alon HerschhornDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
University of Minnesota · US

Funding

DELINEATION AND VULNERABILITIES OF HIV-1 ESCAPE FROM NEUTRALIZING ANTIBODIESDP2DA049279 · NIDA · UNIVERSITY OF MINNESOTA · PI HERSCHHORN, ALON · 2019 to 2019
$2.3M
NIDA NIH HHS DP2 DA049279
6 · The paper itself

Abstract

HIV-1 envelope glycoproteins (Envs) bind to CD4 receptor and CCR5/CXCR4 coreceptor and mediate viral entry (Feng et al., 1996; Herschhorn et al., 2016, 2017; Kwong et al., 1998). HIV-1 Envs are the sole target of neutralizing antibodies and a main focus of vaccine development (Flemming et al., 2018). Here, we provide a step-by-step protocol to measure Env sensitivity to ligands, cold, and small molecules, as well as to study viral infectivity and to dissect parameters affecting HIV-1 Env function. For complete details on the use and execution of this protocol, please refer to Harris et al. (2020).

Indexed as

Antibodies, NeutralizingCD4 AntigensDrug Evaluation, Preclinicalenv Gene Products, Human Immunodeficiency VirusGenes, envGlycoproteinsHIV-1HIV AntibodiesHumansLigandsReceptors, CCR5Virus InternalizationAntibodies, NeutralizingCD4 Antigensenv Gene Products, Human Immunodeficiency VirusGlycoproteinsHIV AntibodiesLigandsReceptors, CCR5

Identifiers

PMID33377027
PMCPMC7757110
OpenAlexW3093348594

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.