Evidence map›Paper›PMID 33376989›Full record

ArticleBrain communications2020

Transcranial magnetic stimulation reveals diminished homoeostatic metaplasticity in cognitively impaired adults.

Mark H Sundman, Koeun Lim, Viet Ton That, Jack-Morgan Mizell, Chidi Ugonna, Rudolph Rodriguez, Nan-Kuei Chen, Andrew J Fuglevand, Yilin Liu, Robert C Wilson and 3 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03652012 (Probing Cortical Excitability and Cognitive Function in Mild Cognitive Impairment With Transcranial Magnetic Stimulation), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03652012 nacompletednot on this map

Probing Cortical Excitability and Cognitive Function in Mild Cognitive Impairment With Transcranial Magnetic Stimulation

TypeinterventionalSponsorUniversity of ArizonaRan2018 to 2020Enrolled40ConditionsCognitive DysfunctionArmsTranscranial Magnetic Stimulation (TMS)
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Mark H SundmanDepartment of Psychology, University of Arizona, Tucson, AZ 85721, USA.
Koeun LimDepartment of Psychology, University of Arizona, Tucson, AZ 85721, USA.
Viet Ton ThatDepartment of Psychology, University of Arizona, Tucson, AZ 85721, USA.
Jack-Morgan MizellDepartment of Psychology, University of Arizona, Tucson, AZ 85721, USA.
Chidi UgonnaDepartment of Biomedical Engineering, University of Arizona, Tucson, AZ 85721, USA.
Rudolph RodriguezDepartment of Psychology, University of Arizona, Tucson, AZ 85721, USA.ORCID 0000-0001-8388-8532
Nan-Kuei ChenDepartment of Biomedical Engineering, University of Arizona, Tucson, AZ 85721, USA.
Andrew J FuglevandDepartment of Physiology, College of Medicine, University of Arizona, Tucson, AZ 85721, USA.
Yilin LiuDepartment of Psychology, University of Arizona, Tucson, AZ 85721, USA.
Robert C WilsonDepartment of Psychology, University of Arizona, Tucson, AZ 85721, USA.ORCID 0000-0002-2963-2971
Jean-Marc FellousDepartment of Psychology, University of Arizona, Tucson, AZ 85721, USA.
Steven RapcsakDepartment of Psychology, University of Arizona, Tucson, AZ 85721, USA.
Ying-Hui ChouDepartment of Psychology, University of Arizona, Tucson, AZ 85721, USA.ORCID 0000-0003-0707-286X
University of Arizona · US

Funding

Research Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI GONZALEZ HERNANDEZ, GRACIELA · 2001 to 2020
$32.5M
Enhancement of Hippocampal Plasticity Using Repetitive Transcranial Magnetic StimulationR01AG062543 · NIA · UNIVERSITY OF ARIZONA · PI CHOU, YING-HUI · 2020 to 2024
$3.5M
Development of High-Speed and Quantitative Neuro MRI Technologies for Challenging Patient PopulationsR01NS102220 · NINDS · UNIVERSITY OF ARIZONA · PI CHEN, NAN-KUEI · 2018 to 2022
$2.1M
NIA NIH HHS P30 AG019610NIA NIH HHS R01 AG062543NINDS NIH HHS R01 NS102220
6 · The paper itself

Abstract

Homoeostatic metaplasticity is a neuroprotective physiological feature that counterbalances Hebbian forms of plasticity to prevent network destabilization and hyperexcitability. Recent animal models highlight dysfunctional homoeostatic metaplasticity in the pathogenesis of Alzheimer's disease. However, the association between homoeostatic metaplasticity and cognitive status has not been systematically characterized in either demented or non-demented human populations, and the potential value of homoeostatic metaplasticity as an early biomarker of cognitive impairment has not been explored in humans. Here, we report that, through pre-conditioning the synaptic activity prior to non-invasive brain stimulation, the association between homoeostatic metaplasticity and cognitive status could be established in a population of non-demented human subjects (older adults across cognitive spectrums; all within the non-demented range). All participants (

Indexed as

cognitive ageingdementiamild cognitive impairmentplasticityTMS

Identifiers

PMID33376989
PMCPMC7750948
OpenAlexW3107081100

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.