Evidence map›Paper›PMID 33376795›Full record

ArticleACS central science2020

Single-Nanoparticle Orientation Sensing by Deep Learning.

Jingtian Hu, Tingting Liu, Priscilla Choo, Shengjie Wang, Thaddeus Reese, Alexander D Sample, Teri W Odom

Open access · diamondAbstract read
In one paragraph

Article in ACS central science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jingtian HuDepartment of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.
Tingting LiuDepartment of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.
Priscilla ChooDepartment of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.
Shengjie WangPaul G. Allen Center for Computer Science & Engineering, University of Washington, Seattle, Washington 98195, United States.
Thaddeus ReeseDepartment of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, United States.
Alexander D SampleDepartment of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.
Teri W OdomDepartment of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.
Northwestern University · USUniversity of Washington · US

Funding

Continuous Probing of Nanoconstruct-Cell Interactions at Biologically Relevant Time ScalesR01GM131421 · NIGMS · NORTHWESTERN UNIVERSITY · PI Teri Wang Odom · 2019 to 2026
$2.1M
NIGMS NIH HHS R01 GM131421
6 · The paper itself

Abstract

This paper describes a computational imaging platform to determine the orientation of anisotropic optical probes under differential interference contrast (DIC) microscopy. We established a deep-learning model based on data sets of DIC images collected from metal nanoparticle optical probes at different orientations. This model predicted the in-plane angle of gold nanorods with an error below 20°, the inherent limit of the DIC method. Using low-symmetry gold nanostars as optical probes, we demonstrated the detection of in-plane particle orientation in the full 0-360° range. We also showed that orientation predictions of the same particle were consistent even with variations in the imaging background. Finally, the deep-learning model was extended to enable simultaneous prediction of in-plane and out-of-plane rotation angles for a multibranched nanostar by concurrent analysis of DIC images measured at multiple wavelengths.

Identifiers

PMID33376795
PMCPMC7760486
OpenAlexW3104698820

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.