ArticleACS central science2020
"Metaphilic" Cell-Penetrating Polypeptide-Vancomycin Conjugate Efficiently Eradicates Intracellular Bacteria via a Dual Mechanism.
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Article in ACS central science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19citing papers in PubMed
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Who cites it
19 citing papers in PubMed.
- α-Helical peptides: design strategies and recent advances in biomedical applications.Journal of translational medicine · 2026Review
- Enzyme-responsive peptide dendron nanoassemblies for targeting and eliminating intracellular drug-resistant bacteria.Nature communications · 2026Article
- Antimicrobial Peptide Nanoassemblies: Design, Response Mechanisms, and Biomedical Applications.Molecules (Basel, Switzerland) · 2026Review
- A methodological approach to improve extracellular staphylococcal clearance in internalization assays using bone-associated host-cell models of orthopedic infections.Frontiers in cellular and infection microbiology · 2026Article
- Harnessing advanced computational approaches to design novel antimicrobial peptides against intracellular bacterial infections.Bioactive materials · 2025Article
- Ion transport in helical-helical polypeptide polymerized ionic liquid block copolymers.Nature communications · 2025Article
- Self-assembling peptide with dual function of cell penetration and antibacterial as a nano weapon to combat intracellular bacteria.Science advances · 2025Article
- Helical peptide structure improves conductivity and stability of solid electrolytes.Nature materials · 2024Article
- Antibacterial Activity of Zinc-Doped Hydroxyapatite and Vancomycin-Loaded Gelatin Nanoparticles against IntracellularACS applied nano materials · 2024Article
- Evaluation of multi-target iridium(iii)-based metallodrugs in combating antimicrobial resistance and infections caused byRSC advances · 2024Article
- Inhibiting the Keap1/Nrf2 Protein-Protein Interaction with Protein-Like Polymers.Advanced materials (Deerfield Beach, Fla.) · 2024Article
- A dual-targeting antifungal is effective against multidrug-resistant human fungal pathogens.Nature microbiology · 2024Article
- Vancomycin-Polyguanidino Dendrimer Conjugates Inhibit Growth of Antibiotic-Resistant Gram-Positive and Gram-Negative Bacteria and Eradicate Biofilm-AssociatedACS infectious diseases · 2024Article
- Peptide-Drug Conjugates: An Emerging Direction for the Next Generation of Peptide Therapeutics.Journal of medicinal chemistry · 2024Review
- Cyanobacteria-based self-oxygenated photodynamic therapy for anaerobic infection treatment and tissue repair.Bioactive materials · 2022Article
- Glyceroglycolipids in marine algae: A review of their pharmacological activity.Frontiers in pharmacology · 2022Review
- Modular Design of Supramolecular Ionic Peptides with Cell-Selective Membrane Activity.Chembiochem : a European journal of chemical biology · 2021Article
- Membrane-disruptive peptides/peptidomimetics-based therapeutics: Promising systems to combat bacteria and cancer in the drug-resistant era.Acta pharmaceutica Sinica. B · 2021Review
- The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions.Chemical Society reviews · 2021Review
Corrections and comments
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Authors and funding
16 authors.
Yunjiang JiangDepartment of Materials Science and Engineering, Beckman Institute for Advanced Science and Technology, Department of Bioegineering, Department of Chemistry, Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Ming HanApplied Physics Graduate Program, Department of Materials Science and Engineering,Department of Engineering Sciences and Applied Mathematics, Department of Chemistry, Department of Physics and Astronomy, Northwestern University, Evanston, Illinois 60208, United States.
Yang BoDepartment of Materials Science and Engineering, Beckman Institute for Advanced Science and Technology, Department of Bioegineering, Department of Chemistry, Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Yujun FengDepartment of Materials Science and Engineering, Beckman Institute for Advanced Science and Technology, Department of Bioegineering, Department of Chemistry, Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Wenming LiDepartment of Materials Science and Engineering, Beckman Institute for Advanced Science and Technology, Department of Bioegineering, Department of Chemistry, Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Jason Ren WuDepartment of Materials Science and Engineering, Beckman Institute for Advanced Science and Technology, Department of Bioegineering, Department of Chemistry, Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Ziyuan SongDepartment of Materials Science and Engineering, Beckman Institute for Advanced Science and Technology, Department of Bioegineering, Department of Chemistry, Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Zihao ZhaoDepartment of Materials Science and Engineering, Beckman Institute for Advanced Science and Technology, Department of Bioegineering, Department of Chemistry, Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Zhengzhong TanDepartment of Materials Science and Engineering, Beckman Institute for Advanced Science and Technology, Department of Bioegineering, Department of Chemistry, Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Yingying ChenDepartment of Materials Science and Engineering, Beckman Institute for Advanced Science and Technology, Department of Bioegineering, Department of Chemistry, Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Tianrui XueDepartment of Materials Science and Engineering, Beckman Institute for Advanced Science and Technology, Department of Bioegineering, Department of Chemistry, Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Zihuan FuDepartment of Materials Science and Engineering, Beckman Institute for Advanced Science and Technology, Department of Bioegineering, Department of Chemistry, Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Shanny Hsuan KuoDepartment of Materials Science and Engineering, Beckman Institute for Advanced Science and Technology, Department of Bioegineering, Department of Chemistry, Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Gee W LauDepartment of Materials Science and Engineering, Beckman Institute for Advanced Science and Technology, Department of Bioegineering, Department of Chemistry, Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Erik LuijtenApplied Physics Graduate Program, Department of Materials Science and Engineering,Department of Engineering Sciences and Applied Mathematics, Department of Chemistry, Department of Physics and Astronomy, Northwestern University, Evanston, Illinois 60208, United States.
Jianjun ChengDepartment of Materials Science and Engineering, Beckman Institute for Advanced Science and Technology, Department of Bioegineering, Department of Chemistry, Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Funding
Precision nanotherapeutics for cancer treatmentR01CA207584 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI FAN, TIMOTHY M · 2017 to 2021
$2.0MNCI NIH HHS R01 CA207584
Abstract
Infections by intracellular pathogens are difficult to treat because of the poor accessibility of antibiotics to the pathogens encased by host cell membranes. As such, a strategy that can improve the membrane permeability of antibiotics would significantly increase their efficiency against the intracellular pathogens. Here, we report the design of an adaptive, metaphilic cell-penetrating polypeptide (CPP)-antibiotic conjugate (VPP-G) that can effectively eradicate the intracellular bacteria both
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.