Evidence map›Paper›PMID 33376737›Full record

ArticleBioMed research international2020

Pyruvate Kinase M2 Knockdown Suppresses Migration, Invasion, and Epithelial-Mesenchymal Transition of Gastric Carcinoma via Hypoxia-Inducible Factor Alpha/B-Cell Lymphoma 6 Pathway.

Ning Li, Dandan Meng, Yue Xu, Ling Gao, Fengqian Shen, Xiaojing Tie, Yan Zhang, Zhenying Yi, Wenjie Shen, Zonglan Liu and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ning LiTumor Diagnosis and Treatment Center of Kaifeng Central Hospital, Kaifeng, 475001 Henan, China.ORCID https://orcid.org/0000-0002-2996-3201
Dandan MengTumor Diagnosis and Treatment Center of Kaifeng Central Hospital, Kaifeng, 475001 Henan, China.ORCID https://orcid.org/0000-0002-9406-9986
Yue XuTumor Diagnosis and Treatment Center of Kaifeng Central Hospital, Kaifeng, 475001 Henan, China.ORCID https://orcid.org/0000-0002-5200-2783
Ling GaoTumor Diagnosis and Treatment Center of Kaifeng Central Hospital, Kaifeng, 475001 Henan, China.ORCID https://orcid.org/0000-0001-9761-9579
Fengqian ShenTumor Diagnosis and Treatment Center of Kaifeng Central Hospital, Kaifeng, 475001 Henan, China.ORCID https://orcid.org/0000-0002-8050-1571
Xiaojing TieTumor Diagnosis and Treatment Center of Kaifeng Central Hospital, Kaifeng, 475001 Henan, China.ORCID https://orcid.org/0000-0003-0133-3336
Yan ZhangTumor Diagnosis and Treatment Center of Kaifeng Central Hospital, Kaifeng, 475001 Henan, China.ORCID https://orcid.org/0000-0001-7760-7685
Zhenying YiTumor Diagnosis and Treatment Center of Kaifeng Central Hospital, Kaifeng, 475001 Henan, China.ORCID https://orcid.org/0000-0001-7348-7428
Wenjie ShenAnalysis Department, Central Hospital of Kaifeng, Kaifeng, 475001 Henan, China.ORCID https://orcid.org/0000-0001-7548-1871
Zonglan LiuAnalysis Department, Central Hospital of Kaifeng, Kaifeng, 475001 Henan, China.ORCID https://orcid.org/0000-0002-0724-3182
Zhiqiao XuTumor Diagnosis and Treatment Center of Kaifeng Central Hospital, Kaifeng, 475001 Henan, China.ORCID https://orcid.org/0000-0003-3039-762X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric carcinoma is a common malignant cancer. Pyruvate kinase M2 (PKM2) is highly expressed in cancers, including gastric carcinoma. However, its function and molecular mechanism in gastric carcinoma remains unclear. Here, we aimed to explore the function and the underlying mechanism of PKM2 on malignant phenotypes in gastric carcinoma. In this study, the mRNA levels and protein levels of PKM2 in gastric carcinoma cell lines and normal gastric mucosa epithelial cell lines were detected using quantitative real-time PCR and western blot, respectively. PKM2 was downregulated by siRNA transfection. HIF-1

Indexed as

Cell MovementGene Expression Regulation, NeoplasticCadherinsCarcinomaCarrier ProteinsCell Line, TumorCell SurvivalEpithelial-Mesenchymal TransitionEpitheliumGene SilencingHumansHypoxia-Inducible Factor 1, alpha SubunitMembrane ProteinsNeoplasm InvasivenessPhenotypeProto-Oncogene Proteins c-bcl-6BCL6 protein, humanCadherinsCarrier ProteinsHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitMembrane ProteinsProto-Oncogene Proteins c-bcl-6RNA, MessengerThyroid Hormone-Binding ProteinsThyroid HormonesVimentin

Identifiers

PMID33376737
PMCPMC7744182
OpenAlexW3112916601

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.