Evidence map›Paper›PMID 33376716›Full record

ArticleBioMed research international2020

Inhibition of

Ping Cai, Yangyang Xie, Mingjun Dong, Qiaoqiao Zhu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ping CaiAnorectal Surgery, Hwa Mei Hospital, University of Chinese Academy of Sciences, 41 Northwest Street Road, Haishu District, Ningbo 315800, China.
Yangyang XieNingbo Institute of Life and Health Industry, University of Chinese Academy of Sciences, 41 Northwest Street Road, Haishu District, Ningbo 315800, China.
Mingjun DongAnorectal Surgery, Hwa Mei Hospital, University of Chinese Academy of Sciences, 41 Northwest Street Road, Haishu District, Ningbo 315800, China.
Qiaoqiao ZhuAnorectal Surgery, Hwa Mei Hospital, University of Chinese Academy of Sciences, 41 Northwest Street Road, Haishu District, Ningbo 315800, China.ORCID https://orcid.org/0000-0001-5502-3291
Blood Center of Zhejiang Province · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAlthough cetuximab has been widely used in the treatment of colon cancer, a large number of patients eventually develop drug resistance. Therefore, it is essential to clarify the mechanism of drug resistance.

methodsIn this study, we combined in silico analysis and a single guide RNA (sgRNA) library to locate cetuximab-sensitive genes. Cell proliferation, apoptosis, and cell cycle were assessed to validate the change in cetuximab sensitivity. Finally, western blotting was performed to detect changes in epidermal growth factor (EGFR) upstream and downstream genes.

resultsUsing in silico analysis and the sgRNA library,

conclusion

Indexed as

Drug Resistance, NeoplasmAntineoplastic Agents, ImmunologicalApoptosisCell CycleCell Line, TumorCell ProliferationCetuximabColonic NeoplasmsHomeodomain ProteinsHumansInhibitory Concentration 50Proto-Oncogene Proteins c-aktProto-Oncogene Proteins c-metRNA, Guide, CRISPR-Cas SystemsSignal TransductionTranscription FactorsAKT1 protein, humanAntineoplastic Agents, ImmunologicalCetuximabHomeodomain ProteinsMEIS3 protein, humanMET protein, humanProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-metRNA, Guide, CRISPR-Cas SystemsTranscription Factors

Identifiers

PMID33376716
PMCPMC7744183
OpenAlexW3113021380

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.