Evidence map›Paper›PMID 33376632›Full record

ArticleBioResearch open access2020

Immunotherapy for Infarcts:

Jun Luo, Matthew S Weaver, Timothy P Fitzgibbons, Myriam Aouadi, Michael P Czech, Margaret D Allen

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioResearch open access, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Jun LuoMatrix Biology Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA.
Matthew S WeaverMatrix Biology Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA.
Timothy P FitzgibbonsCardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Myriam AouadiIntegrated Cardio Metabolic Center, Department of Medicine, Karolinska Institutet, Huddinge, Sweden.
Michael P CzechProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Margaret D AllenMatrix Biology Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA.
Virginia Mason Medical Center · USUniversity of Massachusetts Chan Medical School · USKarolinska Institutet · SE

Funding

Insulin Signaling and Metabolic Regulation in AdipocytesR37DK030898 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CZECH, MICHAEL P · 1996 to 2021
$7.2M
Paracrine Signaling by Kupffer Cells in Hepatic Insulin ResistanceR01DK103047 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CZECH, MICHAEL P · 2015 to 2023
$5.0M
Insulin Signaling and Metabolic Regulation in AdipocytesR01DK030898 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CZECH, MICHAEL P · 1986 to 2011
$2.7M
NIDDK NIH HHS R01 DK030898NIDDK NIH HHS R01 DK103047NIDDK NIH HHS R37 DK030898
6 · The paper itself

Abstract

The myeloid cells infiltrating the heart early after acute myocardial infarction elaborate a secretome that largely orchestrates subsequent ventricular wall repair. Regulating this innate immune response could be a means to improve infarct healing. To pilot this concept, we utilized (β1,3-d-) glucan-encapsulated small interfering RNA (siRNA)-containing particles (GeRPs), targeting mononuclear phagocytes, delivered to mice as a one-time intramyocardial injection immediately after acute infarction. Findings demonstrated that cardiac macrophages phagocytosed GeRPs

Indexed as

intramyocardialmacrophageMap4k4microparticlemyocardial infarctionsiRNA

Identifiers

PMID33376632
PMCPMC7757732
OpenAlexW3108098803

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.