Evidence map›Paper›PMID 33376611›Full record

ArticleCase reports in nephrology2020

Monoclonal Gammopathy of Renal Significance with Deposits of Peculiar Morphology and Injuries of Secondary Thrombotic Microangiopathy: A Case Report and Review of the Literature.

José C De La Flor, Marina Alonso, Edna Sandoval, Alexander Marschall, Miguel Rodeles

Open access · goldAbstract readCase Reports
In one paragraph

Article in Case reports in nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

José C De La FlorDepartment of Nephrology, Hospital Central Defense Gomez Ulla, Madrid, Spain.ORCID https://orcid.org/0000-0001-9346-2279
Marina AlonsoDepartment of Anatomic Pathology, Hospital 12 de Octubre, Madrid, Spain.
Edna SandovalDepartment of Hematology, Hospital Central Defense Gomez Ulla, Madrid, Spain.
Alexander MarschallDepartment of Cardiology, Hospital Central Defense Gomez Ulla, Madrid, Spain.ORCID https://orcid.org/0000-0002-6024-0407
Miguel RodelesDepartment of Nephrology, Hospital Central Defense Gomez Ulla, Madrid, Spain.ORCID https://orcid.org/0000-0001-6503-3119
Hospital Central de la Defensa Gómez Ulla · ESResearch Institute Hospital 12 de Octubre · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present the case of an 82-year-old woman diagnosed with monoclonal gammopathy of renal significance (MGRS) with the presence of different and peculiar kidney lesions, who began treatment with bortezomib and dexamethasone, presenting during her evolution a relapse. Although the bone marrow biopsy in this case showed plasma cells as pathologic clone and there was also a reduction after chemotherapeutic treatment, rituximab was proposed as a second line. We suspected that the relapse was possibly due to another precursor as B-cell or lymphoplasmacytic cell clone. We review the literature and suggest that the treatment for MGRS should be patient-tailored, preferably by consulting a multidisciplinary team. Future research is needed to better understand the disease course and establish the efficacy and safety of the therapeutic approach for the relapse of MGRS.

Identifiers

PMID33376611
PMCPMC7738783
OpenAlexW3112932362

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.